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Ubiquitin
From Proteopedia
(Difference between revisions)
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**[[2kn5]], [[2klg]], [[2jzz]], [[2pe9]], [[2pea]], [[1g6j]], [[1d3z]], [[2kox]], [[2ld9]], [[2k25]] – hUBB – NMR - human<br /> | **[[2kn5]], [[2klg]], [[2jzz]], [[2pe9]], [[2pea]], [[1g6j]], [[1d3z]], [[2kox]], [[2ld9]], [[2k25]] – hUBB – NMR - human<br /> | ||
| - | **[[2ojr]], [[2nr2]], [[2fcq]], [[1ubi]], [[1ubq]], [[1xqq]], [[3ons]] - hUBB<br /> | + | **[[2ojr]], [[2nr2]], [[2fcq]], [[1ubi]], [[1ubq]], [[1xqq]], [[3ons]], [[4wzp]] - hUBB<br /> |
| - | **[[2zcb]], [[2gbj]], [[2gbk]], [[2gbm]], [[2gbn]], [[2gbr]], [[2fcm]], [[2fcn]], [[2fcs]], [[1yiw]], [[1yj1]], [[1sif]], [[1ogw]], [[4hk2]], [[4hjk]] - hUBB (mutant)<br /> | + | **[[2zcb]], [[2gbj]], [[2gbk]], [[2gbm]], [[2gbn]], [[2gbr]], [[2fcm]], [[2fcn]], [[2fcs]], [[1yiw]], [[1yj1]], [[1sif]], [[1ogw]], [[4hk2]], [[4hjk]], [[4pij]], [[4pih]], [[4pig]] - hUBB (mutant)<br /> |
**[[1c3t]], [[1ud7]], [[2mi8]], [[2rsu]], [[2ru6]] - hUBB (mutant) - NMR<br /> | **[[1c3t]], [[1ud7]], [[2mi8]], [[2rsu]], [[2ru6]] - hUBB (mutant) - NMR<br /> | ||
**[[2m0x]] - hUBB - engineered – NMR<br /> | **[[2m0x]] - hUBB - engineered – NMR<br /> | ||
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**[[1e0q]] - hUBB N-terminal (mutant) – NMR<br /> | **[[1e0q]] - hUBB N-terminal (mutant) – NMR<br /> | ||
**[[3q3f]] – hUBB/ribonuclease<br /> | **[[3q3f]] – hUBB/ribonuclease<br /> | ||
| + | **[[4zpz]] – hPolyUBB-B (mutant)<br /> | ||
| + | **[[5af4]], [[4xyz]] – hPolyUBB-C <br /> | ||
| + | **[[5af5]] – hPolyUBB-C (mutant)<br /> | ||
**[[2k39]] – UBB – ''Xenopus laevis'' – NMR<br /> | **[[2k39]] – UBB – ''Xenopus laevis'' – NMR<br /> | ||
**[[2jwz]], [[1zw7]] – yUBB (mutant) – yeast<br /> | **[[2jwz]], [[1zw7]] – yUBB (mutant) – yeast<br /> | ||
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**[[3m3j]], [[1aar]], [[3aui]] – bDiUBB <br /> | **[[3m3j]], [[1aar]], [[3aui]] – bDiUBB <br /> | ||
**[[2bgf]] – hDiUBB – chemical relaxation<br /> | **[[2bgf]] – hDiUBB – chemical relaxation<br /> | ||
| + | **[[4s22]] – bDiUBB <br /> | ||
* Ubiquitin dimer bound to protein | * Ubiquitin dimer bound to protein | ||
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**[[4fjv]] – hDiUBB + UBB thiolesterase <br /> | **[[4fjv]] – hDiUBB + UBB thiolesterase <br /> | ||
**[[4bos]] – hDiUBB + UBB thiolesterase + OTUD2<br /> | **[[4bos]] – hDiUBB + UBB thiolesterase + OTUD2<br /> | ||
| + | **[[4s1z]] – hDiUBB + ZranB1<br /> | ||
* Ubiquitin trimer | * Ubiquitin trimer | ||
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**[[3phd]] – hPolyUBB+histone deacetylase 6<br /> | **[[3phd]] – hPolyUBB+histone deacetylase 6<br /> | ||
**[[3znh]] – hPolyUBB-B + UBB thioesterase<br /> | **[[3znh]] – hPolyUBB-B + UBB thioesterase<br /> | ||
| + | **[[4uf6]] – hPolyUBB-B + UCH-L5 + NF-κ-b-related protein<br /> | ||
**[[3znz]] – hPolyUBB-C + otulin<br /> | **[[3znz]] – hPolyUBB-C + otulin<br /> | ||
**[[4jqw]] – hPolyUBB-C + NOD1 CARD<br /> | **[[4jqw]] – hPolyUBB-C + NOD1 CARD<br /> | ||
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**[[3rul]] – hUBB + dalvancin<br /> | **[[3rul]] – hUBB + dalvancin<br /> | ||
**[[3vfk]] – hUBB + monodechloro-teicoplanin <br /> | **[[3vfk]] – hUBB + monodechloro-teicoplanin <br /> | ||
| - | **[[4ium]] – hUBB+ papain-like protease<br /> | + | **[[4ium]], [[4wur]], [[4mm3]] – hUBB+ papain-like protease<br /> |
**[[2lz6]], [[2mcn]] – hUBB + CD2-associated protein<br /> | **[[2lz6]], [[2mcn]] – hUBB + CD2-associated protein<br /> | ||
**[[2mbh]] – hUBB + Kreuppel-like factor<br /> | **[[2mbh]] – hUBB + Kreuppel-like factor<br /> | ||
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**[[3vht]] – hUBB + GFP<br /> | **[[3vht]] – hUBB + GFP<br /> | ||
**[[4jio]] – hUBB + yBRO1<br /> | **[[4jio]] – hUBB + yBRO1<br /> | ||
| + | **[[5af6]] – hUBB + TRABID<br /> | ||
| + | **[[4un2]] – hUBB + Dsk2 peptide<br /> | ||
| + | **[[4msq]], [[4msm]] – hUBB + AMSH-like protease<br /> | ||
| + | **[[5af6]] – hUBB + TRABID<br /> | ||
| + | **[[4un2]] – hUBB + Dsk2 peptide<br /> | ||
| + | **[[4msq]], [[4msm]] – hUBB + AMSH-like protease<br /> | ||
**[[4m0w]] – bUBB + replicase polyprotein<br /> | **[[4m0w]] – bUBB + replicase polyprotein<br /> | ||
**[[1uzx]] – bUBB+VPS23 UEV<br /> | **[[1uzx]] – bUBB+VPS23 UEV<br /> | ||
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**[[1wr1]] – yUBB+DSK2P UBA<br /> | **[[1wr1]] – yUBB+DSK2P UBA<br /> | ||
**[[1otr]] – yUBB+CUE2<br /> | **[[1otr]] – yUBB+CUE2<br /> | ||
| - | **[[2l00]] – yUBB + Zfand5 | + | **[[2l00]] – yUBB + Zfand5<br /> |
| + | **[[4q5h]], [[4q5e]] – yUBB + UBB conjugating enzyme E2 + OspG<br /> | ||
| + | **[[4nql]] – mUBB + AMSH-like protease<br /> | ||
* Ubiquitin + ions | * Ubiquitin + ions | ||
Revision as of 09:03, 24 June 2015
Image:1d3z.png
NMR Structure of Ubiquitin, 1d3z
Ubiquitin (UBB) is found in almost all cells. It binds to proteins tagging them for destruction in the proteasome. UBB is activated by the UBB-activating enzymes E1, E2 and E3. UBB+1 is a frameshifted mutant of UBB observed in several diseases. A dimer of UBB (DiUBB) is formed by linkage of K48 to the C-terminus of a second UBB molecule. At least 4 UBB molecules are needed to tag a protein for the proteasome. For details see
Additional Resources
See: Ubiquitin Structure & Function for additional information.
3D Structures of Ubiquitin
Updated on 24-June-2015
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Joel L. Sussman, David Canner, Jaime Prilusky
