3wus
From Proteopedia
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| - | ''' | + | ==Crystal Structure of the Vif-Binding Domain of Human APOBEC3F== |
| - | + | <StructureSection load='3wus' size='340' side='right' caption='[[3wus]], [[Resolution|resolution]] 2.54Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3wus]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WUS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WUS FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wus OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wus RCSB], [http://www.ebi.ac.uk/pdbsum/3wus PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | [[ | + | == Function == |
| - | [ | + | [[http://www.uniprot.org/uniprot/ABC3F_HUMAN ABC3F_HUMAN]] DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.<ref>PMID:15152192</ref> <ref>PMID:16527742</ref> <ref>PMID:16378963</ref> <ref>PMID:19458006</ref> <ref>PMID:20219927</ref> <ref>PMID:20335265</ref> <ref>PMID:20062055</ref> <ref>PMID:21496894</ref> <ref>PMID:21835787</ref> <ref>PMID:22915799</ref> <ref>PMID:22807680</ref> <ref>PMID:23097438</ref> <ref>PMID:23152537</ref> |
| - | [ | + | == References == |
| - | [[ | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Iwatani, Y]] | [[Category: Iwatani, Y]] | ||
| + | [[Category: Kawamura, T]] | ||
[[Category: Nakashima, M]] | [[Category: Nakashima, M]] | ||
| + | [[Category: Ode, H]] | ||
| + | [[Category: Watanabe, N]] | ||
| + | [[Category: A3f]] | ||
| + | [[Category: Antiviral enzyme]] | ||
| + | [[Category: Apobec3f]] | ||
| + | [[Category: Cytidine deaminase]] | ||
| + | [[Category: Dna binding]] | ||
| + | [[Category: Hiv-1 vif]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Single-stranded polynucleotide]] | ||
| + | [[Category: Zinc binding]] | ||
Revision as of 12:57, 24 June 2015
Crystal Structure of the Vif-Binding Domain of Human APOBEC3F
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