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4tvr

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'''Unreleased structure'''
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==Tandem Tudor and PHD domains of UHRF2==
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<StructureSection load='4tvr' size='340' side='right' caption='[[4tvr]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
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The entry 4tvr is ON HOLD until Aug 22 2016
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4tvr]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TVR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TVR FirstGlance]. <br>
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Authors: Walker, J.R., Dong, A., Zhang, Q., Ong, M., Duan, S., Li, Y., Bountra, C., Weigelt, J., Edwards, A.M., Arrowsmith, C.H., Tong, Y., STRUCTURAL GENOMICS CONSORTIUM (SGC)
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3oln|3oln]], [[1z6u|1z6u]]</td></tr>
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Description: Tandem Tudor and PHD domains of UHRF2
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tvr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tvr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tvr RCSB], [http://www.ebi.ac.uk/pdbsum/4tvr PDBsum]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/UHRF2_HUMAN UHRF2_HUMAN]] Associated with various cancers. DNA copy number loss is found in multiple kinds of malignancies originating from the brain, breast, stomach, kidney, hematopoietic tissue and lung.
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== Function ==
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[[http://www.uniprot.org/uniprot/UHRF2_HUMAN UHRF2_HUMAN]] E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131.<ref>PMID:12176013</ref> <ref>PMID:15178429</ref> <ref>PMID:14741369</ref> <ref>PMID:15361834</ref> <ref>PMID:21952639</ref> <ref>PMID:23404503</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Arrowsmith, C H]]
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[[Category: Bountra, C]]
[[Category: Dong, A]]
[[Category: Dong, A]]
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[[Category: Duan, S]]
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[[Category: Edwards, A M]]
[[Category: Li, Y]]
[[Category: Li, Y]]
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[[Category: Walker, J.R]]
 
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[[Category: Bountra, C]]
 
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[[Category: Arrowsmith, C.H]]
 
[[Category: Ong, M]]
[[Category: Ong, M]]
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[[Category: Duan, S]]
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[[Category: Structural genomic]]
[[Category: Tong, Y]]
[[Category: Tong, Y]]
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[[Category: Edwards, A.M]]
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[[Category: Walker, J R]]
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[[Category: Structural Genomics Consortium (Sgc)]]
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[[Category: Weigelt, J]]
[[Category: Weigelt, J]]
[[Category: Zhang, Q]]
[[Category: Zhang, Q]]
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[[Category: Ligase]]
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[[Category: Phd]]
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[[Category: Tandem tudor]]

Revision as of 13:00, 24 June 2015

Tandem Tudor and PHD domains of UHRF2

4tvr, resolution 2.29Å

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