Urokinase
From Proteopedia
(Difference between revisions)
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**[[2i9a]] - hUK Hc N terminal (residues 21-163) - human<br /> | **[[2i9a]] - hUK Hc N terminal (residues 21-163) - human<br /> | ||
| + | **[[1urk]] - hUK Hc N terminal – NMR<br /> | ||
**[[1kdu]] – hUK kringle domain (residues 69-153) - NMR<br /> | **[[1kdu]] – hUK kringle domain (residues 69-153) - NMR<br /> | ||
**[[4dva]] – hUK catalytic domain (residues 179-431) <br /> | **[[4dva]] – hUK catalytic domain (residues 179-431) <br /> | ||
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**[[4fu7]], [[4fu8]], [[4fu9]], [[4fub]] - hUK + inhibitor<br /> | **[[4fu7]], [[4fu8]], [[4fu9]], [[4fub]] - hUK + inhibitor<br /> | ||
**[[1fv9]] – hUK (mutant) + benzimidazole derivative – human<br /> | **[[1fv9]] – hUK (mutant) + benzimidazole derivative – human<br /> | ||
| + | **[[4jni]], [[4jnl]] - hUK (mutant) + benzylamine derivative<br /> | ||
**[[1f5k]] - hUK (mutant) + benzamidine derivative<br /> | **[[1f5k]] - hUK (mutant) + benzamidine derivative<br /> | ||
**[[1f5l]] - hUK (mutant) + amiloride derivative<br /> | **[[1f5l]] - hUK (mutant) + amiloride derivative<br /> | ||
| - | **[[1f92]], [[1sc8]], [[1vj9]], [[1vja]], [[2o8t]], [[2o8u]], [[2o8w]], [[4h42]] - hUK (mutant) + inhibitor<br /> | + | **[[1f92]], [[1sc8]], [[1vj9]], [[1vja]], [[2o8t]], [[2o8u]], [[2o8w]], [[4h42]], [[4mnv]] - hUK (mutant) + inhibitor<br /> |
**[[1owd]], [[1owe]], [[1owh]], [[1owi]], [[1owj]], [[1owk]], [[1sqa]], [[1sqo]], [[1u6q]], [[1sqt]], [[4fuc]], [[4fud]], [[4fue]], [[4fuf]], [[4fug]], [[4fuh]], [[4fui]], [[4fuj]]- hUK + naphthamidine inhibitor<br /> | **[[1owd]], [[1owe]], [[1owh]], [[1owi]], [[1owj]], [[1owk]], [[1sqa]], [[1sqo]], [[1u6q]], [[1sqt]], [[4fuc]], [[4fud]], [[4fue]], [[4fuf]], [[4fug]], [[4fuh]], [[4fui]], [[4fuj]]- hUK + naphthamidine inhibitor<br /> | ||
**[[1ejn]] - hUK (mutant) + urea derivative inhibitor<br /> | **[[1ejn]] - hUK (mutant) + urea derivative inhibitor<br /> | ||
**[[2vin]], [[2vio]], [[2vip]], [[2viq]], [[2viv]], [[2viw]] - hUK (mutant) + mexiletine derivative<br /> | **[[2vin]], [[2vio]], [[2vip]], [[2viq]], [[2viv]], [[2viw]] - hUK (mutant) + mexiletine derivative<br /> | ||
**[[3qn7]], [[4jk5]], [[4jk6]] - hUK (mutant) + peptide inhibitor<br /> | **[[3qn7]], [[4jk5]], [[4jk6]] - hUK (mutant) + peptide inhibitor<br /> | ||
| + | **[[4mnw]], [[4mnx]], [[4mny]] - hUK (mutant) + bicyclic peptide <br /> | ||
**[[2vnt]], [[2r2w]] - hUK + guanidine derivative<br /> | **[[2vnt]], [[2r2w]] - hUK + guanidine derivative<br /> | ||
**[[1w0z]], [[1w10]], [[1w11]], [[1w12]], [[1w13]], [[1w14]] - hUK + alanineamide derivative<br /> | **[[1w0z]], [[1w10]], [[1w11]], [[1w12]], [[1w13]], [[1w14]] - hUK + alanineamide derivative<br /> | ||
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**[[2fd6]] – hUK Hc N terminal + antibody + UK receptor<br /> | **[[2fd6]] – hUK Hc N terminal + antibody + UK receptor<br /> | ||
**[[3bt1]], [[3bt2]] - hUK Hc N terminal + vitronectin + UK receptor<br /> | **[[3bt1]], [[3bt2]] - hUK Hc N terminal + vitronectin + UK receptor<br /> | ||
| + | **[[4k24]] - hUK Hc N terminal + vitronectin + antibody<br /> | ||
**[[3laq]], [[3u73]] - hUK Hc N terminal + UK receptor<br /> | **[[3laq]], [[3u73]] - hUK Hc N terminal + UK receptor<br /> | ||
**[[3pb1]] - hUK Hc C terminal (mutant) + UK inhibitor<br /> | **[[3pb1]] - hUK Hc C terminal (mutant) + UK inhibitor<br /> | ||
Revision as of 07:00, 25 June 2015
Urokinase (UK) is a serine protease whose principal substrate is plasminogen – the inactive zymogen of plasmin. UK consists of 3 domains: ligand-binding domain and kringle and growth factor domains. Prourokinase (PUK) is the inactive zymogen of UK which becomes active by proteolytic cleavage into catalytic domain (residues 179-431) and short chain (residues 156-178).
3D Structures of urokinase
Updated on 25-June-2015
