Erythropoietin receptor
From Proteopedia
(Difference between revisions)
(New page: <StructureSection load='1cn4' size='340' side='right' caption='Human erythropoietin receptor complex with erythropoietin (PDB code 1cn4)' scene=''> '''Erythropoietin receptor''' (EpoR...) |
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| - | + | <StructureSection load='1cn4' size='340' side='right' caption='Human erythropoietin receptor (grey and green) complex with erythropoietin (pink) (PDB code [[1cn4]])' scene=''> | |
| - | <StructureSection load='1cn4' size='340' side='right' caption='Human erythropoietin receptor complex with erythropoietin (PDB code [[1cn4]])' scene=''> | + | |
'''Erythropoietin receptor''' (EpoR) is a cytokine receptor. Upon binding of erythropoietin (Epo), EpoR changes from a monomer to a dimer. This change induces the activation of Jak2 kinase via its autophophorylation. Specific tyrosines in the intracellular part of EpoR are phosphorylated and activate various cascades of signal transduction which lead to the formation and maturation of red blood cells. | '''Erythropoietin receptor''' (EpoR) is a cytokine receptor. Upon binding of erythropoietin (Epo), EpoR changes from a monomer to a dimer. This change induces the activation of Jak2 kinase via its autophophorylation. Specific tyrosines in the intracellular part of EpoR are phosphorylated and activate various cascades of signal transduction which lead to the formation and maturation of red blood cells. | ||
Revision as of 07:20, 30 June 2015
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3D Structures of erythropoietin receptor
Updated on 30-June-2015
1ern – hEpoR extracellular domain - human
2mv6 – hEpoR transmembrane domain - NMR
1ebp, 1eba – hEpoR extracellular domain + Epo peptide
1cn4, 1eer – hEpoR extracellular domain (mutant) + Epo (mutant)
2jix – hEpoR extracellular domain + antibody
4y5x, 4y5v – hEpoR extracellular domain + diabody
