3hck
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:3hck.gif|left|200px]] | + | [[Image:3hck.gif|left|200px]] |
| - | + | ||
| - | '''NMR ENSEMBLE OF THE UNCOMPLEXED HUMAN HCK SH2 DOMAIN, 20 STRUCTURES''' | + | {{Structure |
| + | |PDB= 3hck |SIZE=350|CAPTION= <scene name='initialview01'>3hck</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= RESIDUES E119-K224 OF HUMAN HC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | }} | ||
| + | |||
| + | '''NMR ENSEMBLE OF THE UNCOMPLEXED HUMAN HCK SH2 DOMAIN, 20 STRUCTURES''' | ||
| + | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | 3HCK is a [ | + | 3HCK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HCK OCA]. |
==Reference== | ==Reference== | ||
| - | Sequential assignment and secondary structure determination for the Src homology 2 domain of hematopoietic cellular kinase., Zhang W, Smithgall TE, Gmeiner WH, FEBS Lett. 1997 Apr 7;406(1-2):131-5. PMID:[http:// | + | Sequential assignment and secondary structure determination for the Src homology 2 domain of hematopoietic cellular kinase., Zhang W, Smithgall TE, Gmeiner WH, FEBS Lett. 1997 Apr 7;406(1-2):131-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9109402 9109402] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| Line 22: | Line 31: | ||
[[Category: tyrosine kinase]] | [[Category: tyrosine kinase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 19:05:13 2008'' |
Revision as of 17:05, 20 March 2008
| |||||||
| Gene: | RESIDUES E119-K224 OF HUMAN HC (Homo sapiens) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
NMR ENSEMBLE OF THE UNCOMPLEXED HUMAN HCK SH2 DOMAIN, 20 STRUCTURES
Overview
The hematopoietic cellular kinase (Hck) is a member of the Src family of non-receptor protein-tyrosine kinases and participates in signal transduction events regulating the growth, differentiation and function of phagocytes. The secondary structure of the SH2 domain for Hck was determined for a 13C/15N-enriched sample using multi-dimensional NMR spectroscopy. The secondary structure for the domain was determined from chemical shift indices [1H alpha, 13C alpha and 13C'], sequential NOEs [d(alphaN)(i, i+1) and d(NN)(i, i+1)], and 3J(alphaN) scalar coupling constants. The Hck SH2 domain consists of two alpha-helices and seven beta-strands. Complementary strands of beta-sheets were identified from long-range NOEs using a novel 3D, 13C/15N-edited HMQC-NOESY-(HCACO)NH experiment that correlated 1H alpha resonances between beta-strands. The secondary structure for Hck SH2 is similar to that predicted from the sequence alignment of the Src-family protein tyrosine kinases.
About this Structure
3HCK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Sequential assignment and secondary structure determination for the Src homology 2 domain of hematopoietic cellular kinase., Zhang W, Smithgall TE, Gmeiner WH, FEBS Lett. 1997 Apr 7;406(1-2):131-5. PMID:9109402
Page seeded by OCA on Thu Mar 20 19:05:13 2008
