3hsc
From Proteopedia
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| - | [[Image:3hsc.jpg|left|200px]] | + | [[Image:3hsc.jpg|left|200px]] |
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| - | '''THREE-DIMENSIONAL STRUCTURE OF THE ATPASE FRAGMENT OF A 70K HEAT-SHOCK COGNATE PROTEIN''' | + | {{Structure |
| + | |PDB= 3hsc |SIZE=350|CAPTION= <scene name='initialview01'>3hsc</scene>, resolution 1.93Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene> and <scene name='pdbligand=ADP:ADENOSINE-5'-DIPHOSPHATE'>ADP</scene> | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3] | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''THREE-DIMENSIONAL STRUCTURE OF THE ATPASE FRAGMENT OF A 70K HEAT-SHOCK COGNATE PROTEIN''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 3HSC is a [ | + | 3HSC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. This structure supersedes the now removed PDB entries 2HSC and 1HSC. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HSC OCA]. |
==Reference== | ==Reference== | ||
| - | Three-dimensional structure of the ATPase fragment of a 70K heat-shock cognate protein., Flaherty KM, DeLuca-Flaherty C, McKay DB, Nature. 1990 Aug 16;346(6285):623-8. PMID:[http:// | + | Three-dimensional structure of the ATPase fragment of a 70K heat-shock cognate protein., Flaherty KM, DeLuca-Flaherty C, McKay DB, Nature. 1990 Aug 16;346(6285):623-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/2143562 2143562] |
[[Category: Adenosinetriphosphatase]] | [[Category: Adenosinetriphosphatase]] | ||
[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
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[[Category: hydrolase (acting on acid anhydrides)]] | [[Category: hydrolase (acting on acid anhydrides)]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 19:05:20 2008'' |
Revision as of 17:05, 20 March 2008
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| , resolution 1.93Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , and | ||||||
| Activity: | Adenosinetriphosphatase, with EC number 3.6.1.3 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
THREE-DIMENSIONAL STRUCTURE OF THE ATPASE FRAGMENT OF A 70K HEAT-SHOCK COGNATE PROTEIN
Overview
The three-dimensional structure of the amino-terminal 44K ATPase fragment of the 70K bovine heat-shock cognate protein has been solved to a resolution of 2.2 A. The ATPase fragment has two structural lobes with a deep cleft between them; ATP binds at the base of the cleft. Surprisingly, the nucleotide-binding 'core' of the ATPase fragment has a tertiary structure similar to that of hexokinase, although the remainder of the structures of the two proteins are completely dissimilar, suggesting that both the phosphotransferase mechanism and the substrate-induced conformational change intrinsic to the hexokinases may be used by the 70K heat shock-related proteins.
About this Structure
3HSC is a Single protein structure of sequence from Bos taurus. This structure supersedes the now removed PDB entries 2HSC and 1HSC. Full crystallographic information is available from OCA.
Reference
Three-dimensional structure of the ATPase fragment of a 70K heat-shock cognate protein., Flaherty KM, DeLuca-Flaherty C, McKay DB, Nature. 1990 Aug 16;346(6285):623-8. PMID:2143562
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