3il8

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[[Image:3il8.jpg|left|200px]]<br /><applet load="3il8" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:3il8.jpg|left|200px]]
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caption="3il8, resolution 2.0&Aring;" />
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'''CRYSTAL STRUCTURE OF INTERLEUKIN 8: SYMBIOSIS OF NMR AND CRYSTALLOGRAPHY'''<br />
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{{Structure
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|PDB= 3il8 |SIZE=350|CAPTION= <scene name='initialview01'>3il8</scene>, resolution 2.0&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''CRYSTAL STRUCTURE OF INTERLEUKIN 8: SYMBIOSIS OF NMR AND CRYSTALLOGRAPHY'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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3IL8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IL8 OCA].
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3IL8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IL8 OCA].
==Reference==
==Reference==
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Crystal structure of interleukin 8: symbiosis of NMR and crystallography., Baldwin ET, Weber IT, St Charles R, Xuan JC, Appella E, Yamada M, Matsushima K, Edwards BF, Clore GM, Gronenborn AM, et al., Proc Natl Acad Sci U S A. 1991 Jan 15;88(2):502-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=1988949 1988949]
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Crystal structure of interleukin 8: symbiosis of NMR and crystallography., Baldwin ET, Weber IT, St Charles R, Xuan JC, Appella E, Yamada M, Matsushima K, Edwards BF, Clore GM, Gronenborn AM, et al., Proc Natl Acad Sci U S A. 1991 Jan 15;88(2):502-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1988949 1988949]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: preliminary]]
[[Category: preliminary]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:09:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 19:05:28 2008''

Revision as of 17:05, 20 March 2008

Image:3il8.jpg


PDB ID 3il8

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, resolution 2.0Å
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF INTERLEUKIN 8: SYMBIOSIS OF NMR AND CRYSTALLOGRAPHY


Contents

Overview

The crystal structure of a host defense system chemotactic factor, interleukin 8, has been solved by molecular replacement using as a model the solution structure derived from nuclear magnetic resonance experiments. The structure was refined with 2 A x-ray data to an R factor of 0.187 (0.217 at 1.6 A). A comparison indicates some potential differences between the structure in solution and in the crystalline state. Our analysis also predicts that residues 4 through 9 on the amino terminus and the beta-bend, which includes His-33, may be important for receptor binding.

Disease

Known disease associated with this structure: AIDS, slow progression to OMIM:[146929]

About this Structure

3IL8 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of interleukin 8: symbiosis of NMR and crystallography., Baldwin ET, Weber IT, St Charles R, Xuan JC, Appella E, Yamada M, Matsushima K, Edwards BF, Clore GM, Gronenborn AM, et al., Proc Natl Acad Sci U S A. 1991 Jan 15;88(2):502-6. PMID:1988949

Page seeded by OCA on Thu Mar 20 19:05:28 2008

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