3x0e
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Crystal structure of the ectodomain of human CD81 large extracellular loop (hCD81-LEL)== |
| - | + | <StructureSection load='3x0e' size='340' side='right' caption='[[3x0e]], [[Resolution|resolution]] 1.84Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3x0e]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3X0E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3X0E FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1g8q|1g8q]], [[1iv5|1iv5]], [[3x0f|3x0f]], [[3x0g|3x0g]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3x0e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3x0e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3x0e RCSB], [http://www.ebi.ac.uk/pdbsum/3x0e PDBsum]</span></td></tr> | |
| - | [[ | + | </table> |
| - | [[ | + | == Disease == |
| + | [[http://www.uniprot.org/uniprot/CD81_HUMAN CD81_HUMAN]] Defects in CD81 are the cause of immunodeficiency common variable type 6 (CVID6) [MIM:[http://omim.org/entry/613496 613496]]; also called antibody deficiency due to CD81 defect. CVID6 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.<ref>PMID:20237408</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CD81_HUMAN CD81_HUMAN]] May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Cui, S]] | [[Category: Cui, S]] | ||
| + | [[Category: Zhang, M]] | ||
| + | [[Category: Activation]] | ||
| + | [[Category: Cell adhesion]] | ||
| + | [[Category: Differentiation]] | ||
| + | [[Category: Disulfide bond]] | ||
| + | [[Category: Helical bundle]] | ||
| + | [[Category: Immune cell adhesion]] | ||
| + | [[Category: Morphology]] | ||
| + | [[Category: Proliferation]] | ||
Revision as of 12:16, 1 July 2015
Crystal structure of the ectodomain of human CD81 large extracellular loop (hCD81-LEL)
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