4trw
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Structure of BACE1 complex with a syn-HEA-type inhibitor== |
| - | + | <StructureSection load='4trw' size='340' side='right' caption='[[4trw]], [[Resolution|resolution]] 2.85Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4trw]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TRW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TRW FirstGlance]. <br> | |
| - | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LHE:N-[(2R,3S)-3-AMINO-2-HYDROXY-5-METHYLHEXYL]-L-NORVALINE'>LHE</scene>, <scene name='pdbligand=TIH:BETA(2-THIENYL)ALANINE'>TIH</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4trz|4trz]], [[4try|4try]]</td></tr> | |
| - | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4trw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4trw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4trw RCSB], [http://www.ebi.ac.uk/pdbsum/4trw PDBsum]</span></td></tr> |
| - | [[ | + | </table> |
| - | [[Category: | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Memapsin 2]] | ||
[[Category: Akaji, K]] | [[Category: Akaji, K]] | ||
| - | [[Category: Yamashita, E]] | ||
| - | [[Category: Sanjho, A]] | ||
[[Category: Akiyama, T]] | [[Category: Akiyama, T]] | ||
| + | [[Category: Nakagawa, A]] | ||
| + | [[Category: Sanjho, A]] | ||
| + | [[Category: Teruya, K]] | ||
| + | [[Category: Yamashita, E]] | ||
| + | [[Category: Designed inhibitor]] | ||
| + | [[Category: Hydrase proteinase converting]] | ||
| + | [[Category: Hydrase-inhibitor complex]] | ||
| + | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
Revision as of 12:20, 1 July 2015
Structure of BACE1 complex with a syn-HEA-type inhibitor
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