4y5o

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'''Unreleased structure'''
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==CCM2 HHD in complex with MEKK3 NPB1==
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<StructureSection load='4y5o' size='340' side='right' caption='[[4y5o]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
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The entry 4y5o is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4y5o]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y5O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y5O FirstGlance]. <br>
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Authors: Fisher, O.S., Boggon, T.J.
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</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase_kinase_kinase Mitogen-activated protein kinase kinase kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.25 2.7.11.25] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y5o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y5o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4y5o RCSB], [http://www.ebi.ac.uk/pdbsum/4y5o PDBsum]</span></td></tr>
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Description:
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</table>
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[[Category: Unreleased Structures]]
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== Disease ==
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[[Category: Fisher, O.S]]
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[[http://www.uniprot.org/uniprot/CCM2_HUMAN CCM2_HUMAN]] Hereditary cerebral cavernous malformation. The disease is caused by mutations affecting the gene represented in this entry.
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[[Category: Boggon, T.J]]
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== Function ==
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[[http://www.uniprot.org/uniprot/CCM2_HUMAN CCM2_HUMAN]] Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity). [[http://www.uniprot.org/uniprot/M3K3_HUMAN M3K3_HUMAN]] Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators.<ref>PMID:9006902</ref> <ref>PMID:12912994</ref> <ref>PMID:14661019</ref> <ref>PMID:14743216</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Mitogen-activated protein kinase kinase kinase]]
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[[Category: Boggon, T J]]
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[[Category: Fisher, O S]]
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[[Category: Complex]]
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[[Category: Kinase]]
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[[Category: Scaffold]]
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[[Category: Transferase]]

Revision as of 12:24, 1 July 2015

CCM2 HHD in complex with MEKK3 NPB1

4y5o, resolution 2.35Å

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