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4ytg
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Crystal structure of Porphyromonas gingivalis peptidylarginine deiminase (PPAD) mutant C351A in complex with dipeptide Met-Arg.== |
| - | + | <StructureSection load='4ytg' size='340' side='right' caption='[[4ytg]], [[Resolution|resolution]] 1.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4ytg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Porphyromonas_gingivalis Porphyromonas gingivalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YTG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YTG FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene>, <scene name='pdbligand=AZI:AZIDE+ION'>AZI</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CYS:CYSTEINE'>CYS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MET:METHIONINE'>MET</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4yt9|4yt9]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ytg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ytg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ytg RCSB], [http://www.ebi.ac.uk/pdbsum/4ytg PDBsum]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PAD_PORGI PAD_PORGI]] Deiminates the guanidino group of C-terminal arginine residues on a variety of peptides, including the vasoregulatory peptide-hormone bradykinin, to yield ammonia and a citrulline residue. May promote the growth of the pathogen in the periodontal pocket by producing ammonia, ammonia having a protective effect during acidic cleaning cycles in the mouth.<ref>PMID:10377098</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Porphyromonas gingivalis]] | ||
[[Category: Garcia-Ferrer, I]] | [[Category: Garcia-Ferrer, I]] | ||
| - | [[Category: Gomis-Ruth, F | + | [[Category: Gomis-Ruth, F X]] |
| - | + | ||
[[Category: Goulas, T]] | [[Category: Goulas, T]] | ||
| + | [[Category: Guevara, T]] | ||
| + | [[Category: Kantyka, T]] | ||
| + | [[Category: Millan, C]] | ||
| + | [[Category: Mizgalska, D]] | ||
| + | [[Category: Mydel, P]] | ||
[[Category: Potempa, B]] | [[Category: Potempa, B]] | ||
[[Category: Potempa, J]] | [[Category: Potempa, J]] | ||
| - | [[Category: Veillard, F]] | ||
[[Category: Sola, M]] | [[Category: Sola, M]] | ||
| - | [[Category: Mydel, P]] | ||
| - | [[Category: Millan, C]] | ||
[[Category: Sroka, A]] | [[Category: Sroka, A]] | ||
| - | [[Category: Guevara, T]] | ||
| - | [[Category: Mizgalska, D]] | ||
| - | [[Category: Kantyka, T]] | ||
[[Category: Szmigielski, B]] | [[Category: Szmigielski, B]] | ||
| + | [[Category: Uson, I]] | ||
| + | [[Category: Veillard, F]] | ||
| + | [[Category: Citrullination]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Peptidylarginine deiminase]] | ||
Revision as of 12:24, 1 July 2015
Crystal structure of Porphyromonas gingivalis peptidylarginine deiminase (PPAD) mutant C351A in complex with dipeptide Met-Arg.
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