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5bt5

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m (Protected "5bt5" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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==Crystal structure of BRD2 second bromodomain in complex with SGC-CBP30 chemical probe==
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<StructureSection load='5bt5' size='340' side='right' caption='[[5bt5]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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The entry 5bt5 is ON HOLD
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5bt5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BT5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BT5 FirstGlance]. <br>
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Authors: Tallant, C., Hay, D., Krojer, T., Nunez-Alonso, G., Picaud, S., Newman, J.A., Fedorov, O., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Brennan, P.E., Knapp, S., Structural Genomics Consortium (SGC)
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2LO:2-[2-(3-CHLORO-4-METHOXYPHENYL)ETHYL]-5-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)-1-[(2S)-2-(MORPHOLIN-4-YL)PROPYL]-1H-BENZIMIDAZOLE'>2LO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bt5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5bt5 RCSB], [http://www.ebi.ac.uk/pdbsum/5bt5 PDBsum]</span></td></tr>
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Description: Crystal structure of BRD2 second bromodomain in complex with SGC-CBP30 chemical probe
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</table>
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[[Category: Unreleased Structures]]
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== Function ==
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[[Category: Nunez-Alonso, G]]
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[[http://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN]] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Arrowsmith, C H]]
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[[Category: Bountra, C]]
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[[Category: Brennan, P E]]
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[[Category: Delft, F von]]
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[[Category: Edwards, A M]]
[[Category: Fedorov, O]]
[[Category: Fedorov, O]]
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[[Category: Picaud, S]]
 
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[[Category: Knapp, S]]
 
[[Category: Hay, D]]
[[Category: Hay, D]]
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[[Category: Knapp, S]]
[[Category: Krojer, T]]
[[Category: Krojer, T]]
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[[Category: Bountra, C]]
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[[Category: Newman, J A]]
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[[Category: Arrowsmith, C.H]]
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[[Category: Nunez-Alonso, G]]
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[[Category: Von Delft, F]]
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[[Category: Picaud, S]]
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[[Category: Edwards, A.M]]
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[[Category: Structural genomic]]
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[[Category: Brennan, P.E]]
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[[Category: Newman, J.A]]
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[[Category: Structural Genomics Consortium (Sgc)]]
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[[Category: Tallant, C]]
[[Category: Tallant, C]]
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[[Category: Acetylation]]
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[[Category: Chromatin and transcription regulator]]
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[[Category: Sgc]]
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[[Category: Transcription]]

Revision as of 12:28, 1 July 2015

Crystal structure of BRD2 second bromodomain in complex with SGC-CBP30 chemical probe

5bt5, resolution 1.40Å

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