Hydroxysteroid dehydrogenase
From Proteopedia
(Difference between revisions)
| Line 25: | Line 25: | ||
**[[1ral]] – rHSD – rat<BR /> | **[[1ral]] – rHSD – rat<BR /> | ||
**[[1fjh]] - CtHSD – ''Comamonas testosterone''<BR /> | **[[1fjh]] - CtHSD – ''Comamonas testosterone''<BR /> | ||
| - | **[[3fjn]] - mHSD (mutant) - mouse<br /> | ||
**[[4is2]] – CsHSD – ''Clostridium scindens''<br /> | **[[4is2]] – CsHSD – ''Clostridium scindens''<br /> | ||
| Line 33: | Line 32: | ||
**[[1fk8]] – CtHSD + NAD<BR /> | **[[1fk8]] – CtHSD + NAD<BR /> | ||
**[[2fvl]], [[2hdj]] - hHSD + NADP<BR /> | **[[2fvl]], [[2hdj]] - hHSD + NADP<BR /> | ||
| - | **[[2dkn]] - HSD + NAD – ''Pseudomonas'' | + | **[[2dkn]] - HSD + NAD – ''Pseudomonas''<BR /> |
| - | + | ||
**[[4is3]] - CsHSD + NAD<br /> | **[[4is3]] - CsHSD + NAD<br /> | ||
*''3-α HSD ternary complex'' | *''3-α HSD ternary complex'' | ||
| - | **[[1ihi]], [[1j96]] - hHSD + hydroxysteroid + NADP – human<BR /> | ||
**[[1afs]] - rHSD + hydroxysteroid + NADP<BR /> | **[[1afs]] - rHSD + hydroxysteroid + NADP<BR /> | ||
| - | **[[ | + | **[[4jq1]], [[4jq2]], [[4jq3]], [[4jqa]], [[4jqa]], [[4jtq]], [[4jtr]] - hHSD + NSAID drug + NADP - human<br /> |
| - | **[[ | + | |
| - | **[[ | + | *3-α HSD type 3 |
| + | |||
| + | **[[2hdj]] - hHSD + NADP<br /> | ||
| + | **[[1ihi]], [[1j96]] - hHSD + hydroxysteroid + NADP <br /> | ||
| + | **[[1xjb]] - hHSD + citrate+ acetate + NADP<br /> | ||
| + | **[[4l1w]] - hHSD + progesterone + NADP<br /> | ||
| + | **[[4l1x]] - hHSD (mutant) + progesterone + NADP<br /> | ||
*7-α HSD | *7-α HSD | ||
| Line 81: | Line 84: | ||
**[[2irw]], [[2ilt]], [[4bb5]], [[4bb6]] - hHSD 1 + inhibitor + NADP<BR /> | **[[2irw]], [[2ilt]], [[4bb5]], [[4bb6]] - hHSD 1 + inhibitor + NADP<BR /> | ||
**[[2rbe]], [[3byz]], [[3bzu]], [[3ch6]], [[3czr]], [[3d3e]], [[3d4n]], [[3d5q]], [[3ey4]], [[3frj]], [[3hfg]], [[3fco]], [[3h6k]], [[3oq1]], [[3pdj]], [[3tfq]], [[3qqp]], [[4c7j]], [[4c7k]], [[4p38]] - hHSD 1 (mutant) + inhibitor + NADP<BR /> | **[[2rbe]], [[3byz]], [[3bzu]], [[3ch6]], [[3czr]], [[3d3e]], [[3d4n]], [[3d5q]], [[3ey4]], [[3frj]], [[3hfg]], [[3fco]], [[3h6k]], [[3oq1]], [[3pdj]], [[3tfq]], [[3qqp]], [[4c7j]], [[4c7k]], [[4p38]] - hHSD 1 (mutant) + inhibitor + NADP<BR /> | ||
| + | |||
| + | *17-α HSD | ||
| + | |||
| + | **[[3fjn]] - mHSD (mutant) - mouse<br /> | ||
| + | **[[2p5n]] - mHSD + NADP <br /> | ||
| + | **[[2ipf]] - mHSD + hydroxysteroid + NADP <br /> | ||
| + | **[[2ipg]], [[2ipj]] - mHSD (mutant) + hydroxysteroid + NADP<br /> | ||
| + | **[[3cv6]] - mHSD (mutant) + inhibitor + NADP<br /> | ||
*17-β HSD | *17-β HSD | ||
Revision as of 10:53, 2 July 2015
Template:STRUCTURE 1lwi
Hydroxysteroid dehydrogenase (HSD) catalyzes the dehydrogenation of hydroxysteroids. HSD is classified according to the number of carbon it is acting on.
- 3-α HSD catalyzes the conversion of androsterone to 5α-androstane-3, 17-dione and 17-α estradiol to estrone. 3-α HSD (also named 17-α HSD) is a bile acid-metabolizing enzyme.
- 7-α HSD is involved in the dehydrogenation of cholanate compounds and is a bile acid-inducible enzyme.
- 20-α HSD is involved in the control of progesterone level in pregnancy of mice.
- 11-β HSD converts 11-keto products like cortisone to cortisol.
- 17-β HSD is involved in the conversion of androstenedione to testosterone.
- 3-β/17-β HSD catalyzes the reversible dehydrogenation of steroid compounds at position 3 and 17.
NAD and NADP are cofactors of HSD.
3D structures of hydroxysteroid dehydrogenase
Updated on 02-July-2015
For 3-α HSD type 2 see Prostaglandin F synthase
For 17-β HSD type 5 see Prostaglandin F synthase
