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4wgk
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Crystal structure of human neutral ceramidase with Zn-bound phosphate== |
| - | + | <StructureSection load='4wgk' size='340' side='right' caption='[[4wgk]], [[Resolution|resolution]] 2.58Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4wgk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WGK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WGK FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ceramidase Ceramidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.23 3.5.1.23] </span></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wgk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wgk RCSB], [http://www.ebi.ac.uk/pdbsum/4wgk PDBsum]</span></td></tr> | |
| - | [[Category: | + | </table> |
| - | [[Category: Hannun, Y | + | == Function == |
| - | [[Category: Obeid, L | + | [[http://www.uniprot.org/uniprot/ASAH2_HUMAN ASAH2_HUMAN]] Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-8.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Acts as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, and generating sphingosine, a precursor of the antiapoptotic factor sphingosine 1-phosphate. Probably involved in the digestion of dietary sphingolipids in intestine by acting as a key enzyme for the catabolism of dietary sphingolipids and regulating the levels of bioactive sphingolipid metabolites in the intestinal tract.<ref>PMID:15946935</ref> <ref>PMID:16061940</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Ceramidase]] | ||
| + | [[Category: Airola, M V]] | ||
| + | [[Category: Hannun, Y A]] | ||
| + | [[Category: Obeid, L M]] | ||
| + | [[Category: Pulkoski-Gross, M J]] | ||
| + | [[Category: Amidase]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Phosphate]] | ||
| + | [[Category: Zinc]] | ||
Revision as of 14:52, 8 July 2015
Crystal structure of human neutral ceramidase with Zn-bound phosphate
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Categories: Ceramidase | Airola, M V | Hannun, Y A | Obeid, L M | Pulkoski-Gross, M J | Amidase | Hydrolase | Phosphate | Zinc
