4zrl
From Proteopedia
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| - | ''' | + | ==Structure of the non canonical Poly(A) polymerase complex GLD-2 - GLD-3== |
| - | + | <StructureSection load='4zrl' size='340' side='right' caption='[[4zrl]], [[Resolution|resolution]] 2.28Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4zrl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZRL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZRL FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | |
| - | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |
| - | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Polynucleotide_adenylyltransferase Polynucleotide adenylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.19 2.7.7.19] </span></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zrl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zrl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4zrl RCSB], [http://www.ebi.ac.uk/pdbsum/4zrl PDBsum]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GLD2_CAEEL GLD2_CAEEL]] Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. Acts as a regulator of mitosis/meiosis required for progression through meiotic prophase during oogenesis and spermatogenesis and for promotion of the entry into meiosis from the mitotic cell cycle. May act by regulating and activating gld-1 mRNA activity in germline.<ref>PMID:12239571</ref> <ref>PMID:14660440</ref> <ref>PMID:15063172</ref> <ref>PMID:15514056</ref> <ref>PMID:15911573</ref> <ref>PMID:17012378</ref> <ref>PMID:9550713</ref> [[http://www.uniprot.org/uniprot/GLD3_CAEEL GLD3_CAEEL]] Required maternally for germline survival and embryogenesis. Forms a complex with gls-1 which promotes the oogenic cell fate by freeing the translational repressor fbf to repress sperm promoting factors. Promotes maturation of primary spermatocytes to mature sperm. Required during hermaphrodite development to promote sperm fate, which is critical for determining the normal number of sperm. Promotion of sperm fate is at the expense of oogenesis, possibly through the negative regulation of fbf. Required during male development for the continued production of sperm and inhibition of oogenesis. Together with gld-2, promotes the transition from mitosis to meiosis.<ref>PMID:12431376</ref> <ref>PMID:15454534</ref> <ref>PMID:19461891</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Polynucleotide adenylyltransferase]] | ||
[[Category: Bonneau, F]] | [[Category: Bonneau, F]] | ||
| - | [[Category: Eckmann, C.R]] | ||
| - | [[Category: Nakel, K]] | ||
[[Category: Conti, E]] | [[Category: Conti, E]] | ||
| + | [[Category: Eckmann, C R]] | ||
| + | [[Category: Nakel, K]] | ||
| + | [[Category: Polyadenylation]] | ||
| + | [[Category: Post-transcriptional regulation]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 14:54, 8 July 2015
Structure of the non canonical Poly(A) polymerase complex GLD-2 - GLD-3
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