5c7n
From Proteopedia
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| - | ''' | + | ==Crystal structure of the human BRPF1 bromodomain in complex with Bromosporine== |
| - | + | <StructureSection load='5c7n' size='340' side='right' caption='[[5c7n]], [[Resolution|resolution]] 1.75Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5c7n]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C7N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5C7N FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMF:BROMOSPORINE'>BMF</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5c7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c7n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5c7n RCSB], [http://www.ebi.ac.uk/pdbsum/5c7n PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | [[ | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/BRPF1_HUMAN BRPF1_HUMAN]] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.<ref>PMID:16387653</ref> <ref>PMID:18794358</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Caflisch, A]] | [[Category: Caflisch, A]] | ||
[[Category: Zhu, J]] | [[Category: Zhu, J]] | ||
| + | [[Category: Bromodomain and phd finger-containing protein 1]] | ||
| + | [[Category: Dna binding protein]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 14:57, 8 July 2015
Crystal structure of the human BRPF1 bromodomain in complex with Bromosporine
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