5c8h

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m (Protected "5c8h" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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==Crystal structure of ORC2 C-terminal domain==
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<StructureSection load='5c8h' size='340' side='right' caption='[[5c8h]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
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The entry 5c8h is ON HOLD
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5c8h]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C8H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5C8H FirstGlance]. <br>
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Authors: Tempel, W., Xu, Z., Dong, A., Loppnau, P., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5c8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c8h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5c8h RCSB], [http://www.ebi.ac.uk/pdbsum/5c8h PDBsum]</span></td></tr>
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Description: Crystal structure of ORC2 C-terminal domain
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</table>
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[[Category: Unreleased Structures]]
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== Function ==
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[[http://www.uniprot.org/uniprot/ORC2_HUMAN ORC2_HUMAN]] Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3.<ref>PMID:22427655</ref> <ref>PMID:22935713</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Arrowsmith, C H]]
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[[Category: Bountra, C]]
[[Category: Dong, A]]
[[Category: Dong, A]]
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[[Category: Edwards, A M]]
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[[Category: Loppnau, P]]
[[Category: Min, J]]
[[Category: Min, J]]
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[[Category: Bountra, C]]
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[[Category: Structural genomic]]
[[Category: Tempel, W]]
[[Category: Tempel, W]]
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[[Category: Loppnau, P]]
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[[Category: Xu, C]]
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[[Category: Arrowsmith, C.H]]
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[[Category: Dna replication]]
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[[Category: Edwards, A.M]]
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[[Category: Replication]]
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[[Category: Xu, Z]]
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[[Category: Sgc]]
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[[Category: Structural Genomics Consortium (Sgc)]]
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Revision as of 14:57, 8 July 2015

Crystal structure of ORC2 C-terminal domain

5c8h, resolution 2.01Å

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