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5c8h
From Proteopedia
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| - | ''' | + | ==Crystal structure of ORC2 C-terminal domain== |
| - | + | <StructureSection load='5c8h' size='340' side='right' caption='[[5c8h]], [[Resolution|resolution]] 2.01Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5c8h]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C8H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5C8H FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5c8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c8h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5c8h RCSB], [http://www.ebi.ac.uk/pdbsum/5c8h PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | [[Category: | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/ORC2_HUMAN ORC2_HUMAN]] Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3.<ref>PMID:22427655</ref> <ref>PMID:22935713</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Arrowsmith, C H]] | ||
| + | [[Category: Bountra, C]] | ||
[[Category: Dong, A]] | [[Category: Dong, A]] | ||
| + | [[Category: Edwards, A M]] | ||
| + | [[Category: Loppnau, P]] | ||
[[Category: Min, J]] | [[Category: Min, J]] | ||
| - | [[Category: | + | [[Category: Structural genomic]] |
[[Category: Tempel, W]] | [[Category: Tempel, W]] | ||
| - | [[Category: | + | [[Category: Xu, C]] |
| - | + | [[Category: Dna replication]] | |
| - | [[Category: | + | [[Category: Replication]] |
| - | [[Category: | + | [[Category: Sgc]] |
| - | [[Category: | + | |
Revision as of 14:57, 8 July 2015
Crystal structure of ORC2 C-terminal domain
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Categories: Arrowsmith, C H | Bountra, C | Dong, A | Edwards, A M | Loppnau, P | Min, J | Structural genomic | Tempel, W | Xu, C | Dna replication | Replication | Sgc
