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Phospholamban
From Proteopedia
(New page: <StructureSection load='4y3u' size='340' side='right' caption='Dog phospholamban complex with calcium pump (PDB code 4y3u)' scene=''> Phospholamban (PLB) is a 52-amino acid membrane p...) |
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| - | + | <StructureSection load='4y3u' size='340' side='right' caption='Dog phospholamban (green and pink) complex with calcium pump (grey) and K+ ion (purple) (PDB code [[4y3u]])' scene=''> | |
| - | <StructureSection load='4y3u' size='340' side='right' caption='Dog phospholamban complex with calcium pump (PDB code [[4y3u]])' scene=''> | + | '''Phospholamban''' (PLB) is a 52-amino acid membrane protein that regulates the Ca+2 pump in cardiac and skeletal muscle cells. PLB functions as a homopentamer and is an inhibitor of Ca+2-ATPase in its unphosphorylated state. When PLB is phosphorylated by protein kinase A, it dissociates from Ca+2-ATPase and its inhibitory function is lost resulting in increase of ATPase activity. |
| - | Phospholamban (PLB) is a 52-amino acid membrane protein that regulates the Ca+2 pump in cardiac and skeletal muscle cells. PLB functions as a homopentamer and is an inhibitor of Ca+2-ATPase in its unphosphorylated state. When PLB is phosphorylated by protein kinase A, it dissociates from Ca+2-ATPase and its inhibitory function is lost resulting in increase of ATPase activity. | + | |
== Function == | == Function == | ||
Revision as of 10:12, 13 July 2015
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3D Structures of phospholamban
Updated on 13-July-2015
1plp – hPLB cytoplasmic domain – human - NMR
1zll, 2hyn – hPLB - NMR
1fjk, 1fjp – PLB – pig - NMR
1n7l, 2lpf – rPLB (mutant) – rabbit - NMR
2m3b – rPLB - NMR
2kb7, 2kyv – PLB – Escherichia coli - NMR
4kyt – dPLB (mutant) + calcium pump – dog
4y3u – dPLB + calcium pump
