4yns

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m (Protected "4yns" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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==A tethered niacin-derived pincer complex with a nickel-carbon bond in lactate racemase==
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<StructureSection load='4yns' size='340' side='right' caption='[[4yns]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4yns]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YNS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YNS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4EY:1-[(2R,3R,4S,5R)-3,4-BIS(OXIDANYL)-5-(PHOSPHONOOXYMETHYL)OXOLAN-2-YL]-5-METHANETHIOYL-PYRIDINE-3-CARBOTHIOIC+S-ACID'>4EY</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yns FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yns OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4yns RCSB], [http://www.ebi.ac.uk/pdbsum/4yns PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Lactic acid racemization is involved in lactate metabolism and cell wall assembly of many microorganisms. Lactate racemase (Lar) requires nickel, but the nickel-binding site and the role of three accessory proteins required for its activation remain enigmatic. We combined mass spectrometry and x-ray crystallography to show that Lar from Lactobacillus plantarum possesses an organometallic nickel-containing prosthetic group. A nicotinic acid mononucleotide derivative is tethered to Lys(184) and forms a tridentate pincer complex that coordinates nickel through one metal-carbon and two metal-sulfur bonds, with His(200) as another ligand. Although similar complexes have been previously synthesized, there was no prior evidence for the existence of pincer cofactors in enzymes. The wide distribution of the accessory proteins without Lar suggests that it may play a role in other enzymes.
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The entry 4yns is ON HOLD
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METALLOPROTEINS. A tethered niacin-derived pincer complex with a nickel-carbon bond in lactate racemase.,Desguin B, Zhang T, Soumillion P, Hols P, Hu J, Hausinger RP Science. 2015 Jul 3;349(6243):66-9. doi: 10.1126/science.aab2272. PMID:26138974<ref>PMID:26138974</ref>
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Authors: Desguin, B., Zhang, T., Soumillion, P., Hols, P., Hu, J., Hausinger, R.P.
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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Description: Crystal Structure of a Lactate Racemase (LarA) from Lactobacillus plantarum
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Desguin, B]]
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[[Category: Hausinger, R P]]
[[Category: Hols, P]]
[[Category: Hols, P]]
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[[Category: Zhang, T]]
 
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[[Category: Desguin, B]]
 
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[[Category: Hausinger, R.P]]
 
[[Category: Hu, J]]
[[Category: Hu, J]]
[[Category: Soumillion, P]]
[[Category: Soumillion, P]]
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[[Category: Zhang, T]]
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[[Category: Cofactor]]
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[[Category: Isomerase]]
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[[Category: Lactate]]
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[[Category: Nickel]]
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[[Category: Racemase]]

Revision as of 13:23, 15 July 2015

A tethered niacin-derived pincer complex with a nickel-carbon bond in lactate racemase

4yns, resolution 3.00Å

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