3wuu
From Proteopedia
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| - | ''' | + | ==Structure basis of inactivating cell abscission with chimera peptide 1== |
| - | + | <StructureSection load='3wuu' size='340' side='right' caption='[[3wuu]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3wuu]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WUU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WUU FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3wut|3wut]], [[3wuv|3wuv]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wuu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wuu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wuu RCSB], [http://www.ebi.ac.uk/pdbsum/3wuu PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | [[Category: | + | == Function == |
| - | [[Category: Lee, H | + | [[http://www.uniprot.org/uniprot/CEP55_HUMAN CEP55_HUMAN]] Plays a role in mitotic exit and cytokinesis. Not required for microtubule nucleation. Recruits PDCD6IP and TSG101 to midbody during cytokinesis.<ref>PMID:16198290</ref> <ref>PMID:17853893</ref> [[http://www.uniprot.org/uniprot/TEX14_HUMAN TEX14_HUMAN]] Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro (By similarity). |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Kim, H J]] | ||
| + | [[Category: Lee, H H]] | ||
[[Category: Matsuura, A]] | [[Category: Matsuura, A]] | ||
| - | [[Category: | + | [[Category: Cell cycle]] |
| + | [[Category: Coiled-coil]] | ||
Revision as of 13:29, 15 July 2015
Structure basis of inactivating cell abscission with chimera peptide 1
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