4wtv
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Crystal structure of the phosphatidylinositol 4-kinase IIbeta== |
| - | + | <StructureSection load='4wtv' size='340' side='right' caption='[[4wtv]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4wtv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WTV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WTV FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wtv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wtv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wtv RCSB], [http://www.ebi.ac.uk/pdbsum/4wtv PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | [[Category: | + | [[http://www.uniprot.org/uniprot/P4K2B_HUMAN P4K2B_HUMAN]] Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking.<ref>PMID:11923287</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Baumlova, A]] | ||
[[Category: Boura, E]] | [[Category: Boura, E]] | ||
[[Category: Chalupska, D]] | [[Category: Chalupska, D]] | ||
| - | [[Category: | + | [[Category: Klima, M]] |
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Lipid kinase]] | ||
| + | [[Category: Phosphatidyl inositol]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 13:34, 15 July 2015
Crystal structure of the phosphatidylinositol 4-kinase IIbeta
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