Tissue factor pathway inhibitor
From Proteopedia
(Difference between revisions)
(New page: <StructureSection load='1tfx' size='340' side='right' caption='Human tissue factor pathway inhibitor I kunitz domai II complex with trypsin (PDB code 1tfx) comp' scene=''> '''Tissue f...) |
|||
| Line 1: | Line 1: | ||
| - | + | <StructureSection load='1tfx' size='340' side='right' caption='Human tissue factor pathway inhibitor I kunitz domai II (grey and green) complex with trypsin (pink and yellow) and Ca+2 ion (PDB code [[1tfx]]) comp' scene=''> | |
| - | <StructureSection load='1tfx' size='340' side='right' caption='Human tissue factor pathway inhibitor I kunitz domai II complex with trypsin (PDB code [[1tfx]]) comp' scene=''> | + | |
'''Tissue factor pathway inhibitor''' (TFPI) is a protease inhibitor which inhibits coagulation factor Xa and VIIa. TFPI contains three Kunitz domains. The Kunitz domain is disulfide-rich and is arranged to form a twisted two-stranded antiparallel b sheet followed by an a helix. Kunitz I domain inhibits VIIa coagulation factor while Kunitz II domain inhibits Xa. | '''Tissue factor pathway inhibitor''' (TFPI) is a protease inhibitor which inhibits coagulation factor Xa and VIIa. TFPI contains three Kunitz domains. The Kunitz domain is disulfide-rich and is arranged to form a twisted two-stranded antiparallel b sheet followed by an a helix. Kunitz I domain inhibits VIIa coagulation factor while Kunitz II domain inhibits Xa. | ||
| Line 9: | Line 8: | ||
== Relevance == | == Relevance == | ||
| - | == Structural highlights == | + | == Structural highlights == |
</StructureSection> | </StructureSection> | ||
Revision as of 06:39, 16 July 2015
| |||||||||||
3D Structures of tissue factor pathway inhibitor
Updated on 16-July-2015
1adz – hTFPI-1 kunitz domain II (mutant) – human - NMR
1irh – hTFPI-1 kunitz domain III - NMR
1tfx – hTFPI-1 kunitz domain II + trypsin
1zr0 – hTFPI-2 kunitz domain I + trypsin
4dtg – hTFPI-1 kunitz domain II + antibody
4bqd – hTFPI-1 kunitz domain I + peptide
