5bna

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[[Image:5bna.jpg|left|200px]]<br /><applet load="5bna" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:5bna.jpg|left|200px]]
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caption="5bna, resolution 2.600&Aring;" />
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'''THE PRIMARY MODE OF BINDING OF CISPLATIN TO A B-DNA DODECAMER: C-G-C-G-A-A-T-T-C-G-C-G'''<br />
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{{Structure
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|PDB= 5bna |SIZE=350|CAPTION= <scene name='initialview01'>5bna</scene>, resolution 2.600&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=PTN:PLATINUM TRIAMINE ION'>PTN</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''THE PRIMARY MODE OF BINDING OF CISPLATIN TO A B-DNA DODECAMER: C-G-C-G-A-A-T-T-C-G-C-G'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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5BNA is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=PTN:'>PTN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BNA OCA].
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5BNA is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BNA OCA].
==Reference==
==Reference==
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The primary mode of binding of cisplatin to a B-DNA dodecamer: C-G-C-G-A-A-T-T-C-G-C-G., Wing RM, Pjura P, Drew HR, Dickerson RE, EMBO J. 1984 May;3(5):1201-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=6539674 6539674]
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The primary mode of binding of cisplatin to a B-DNA dodecamer: C-G-C-G-A-A-T-T-C-G-C-G., Wing RM, Pjura P, Drew HR, Dickerson RE, EMBO J. 1984 May;3(5):1201-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/6539674 6539674]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Dickerson, R E.]]
[[Category: Dickerson, R E.]]
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[[Category: modified]]
[[Category: modified]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:14:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 19:11:38 2008''

Revision as of 17:11, 20 March 2008

Image:5bna.jpg


PDB ID 5bna

Drag the structure with the mouse to rotate
, resolution 2.600Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



THE PRIMARY MODE OF BINDING OF CISPLATIN TO A B-DNA DODECAMER: C-G-C-G-A-A-T-T-C-G-C-G


Overview

When cisplatin [cis- diamminodichloroplatinum (II)] is diffused into pre-grown crystals of the B-DNA double-helical dodecamer C-G-C-G-A-A-T-T-C-G-C-G, it binds preferentially to the N7 positions of guanines, with what probably is an aquo bridge between Pt and the adjacent O6 atom of the same guanine. The entire guanine ring moves slightly toward the platinum site, into the major groove. Only three of the eight potential cisplatin binding sites on guanines actually are occupied, and this differential reactivity can be explained in terms of the relative freedom of motion of guanines toward the major groove. This shift of guanines upon ligation may weaken the glycosyl bond and assist in the depurination that leads to mismatch SOS repair and G.C. to T.A. transversion.

About this Structure

5BNA is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

The primary mode of binding of cisplatin to a B-DNA dodecamer: C-G-C-G-A-A-T-T-C-G-C-G., Wing RM, Pjura P, Drew HR, Dickerson RE, EMBO J. 1984 May;3(5):1201-6. PMID:6539674

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