5chb
From Proteopedia
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| - | ''' | + | ==Crystal structure of nvPizza2-S16H58 coordinating a CdCl2 nanocrystal== |
| + | <StructureSection load='5chb' size='340' side='right' caption='[[5chb]], [[Resolution|resolution]] 1.55Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5chb]] is a 3 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4zco 4zco]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CHB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CHB FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5chb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5chb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5chb RCSB], [http://www.ebi.ac.uk/pdbsum/5chb PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | We have engineered a metal-binding site into the novel artificial beta-propeller protein Pizza. This new Pizza variant carries two nearly identical domains per polypeptide chain, and forms a trimer with three-fold symmetry. The designed single metal ion binding site lies on the symmetry axis, bonding the trimer together. Two copies of the trimer associate in the presence of cadmium chloride in solution, and very high-resolution X-ray crystallographic analysis reveals a nanocrystal of cadmium chloride, sandwiched between two trimers of the protein. This nanocrystal, containing seven cadmium ions lying in a plane and twelve interspersed chloride ions, is the smallest reported to date. Our results indicate the feasibility of using rationally designed symmetrical proteins to biomineralize nanocrystals with useful properties. | ||
| - | + | Biomineralization of a Cadmium Chloride Nanocrystal by a Designed Symmetrical Protein.,Voet AR, Noguchi H, Addy C, Zhang KY, Tame JR Angew Chem Int Ed Engl. 2015 Jul 1. doi: 10.1002/anie.201503575. PMID:26136355<ref>PMID:26136355</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Addy, C]] | ||
[[Category: Noguchi, H]] | [[Category: Noguchi, H]] | ||
| - | [[Category: Voet, A | + | [[Category: Tame, J R.H]] |
| - | [[Category: Zhang, K | + | [[Category: Voet, A R.D]] |
| - | [[Category: | + | [[Category: Zhang, K Y.J]] |
| - | [[Category: | + | [[Category: Biomineralization]] |
| + | [[Category: Cadmium]] | ||
| + | [[Category: Computational protein design]] | ||
| + | [[Category: De novo protein]] | ||
| + | [[Category: Metalloprotein]] | ||
| + | [[Category: Nano-crystal]] | ||
| + | [[Category: Symmetrical protein]] | ||
Revision as of 14:02, 22 July 2015
Crystal structure of nvPizza2-S16H58 coordinating a CdCl2 nanocrystal
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