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4use

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'''Unreleased structure'''
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==Human STK10 (LOK) with SB-633825==
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<StructureSection load='4use' size='340' side='right' caption='[[4use]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
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The entry 4use is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4use]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4USE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4USE FirstGlance]. <br>
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Authors: Elkins, J.M., Salah, E., Szklarz, M., vonDelft, F., Canning, P., Raynor, J., Bountra, C., Edwards, A.M., Knapp, S.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=R09:4-{5-(6-METHOXYNAPHTHALEN-2-YL)-1-METHYL-2-[2-METHYL-4-(METHYLSULFONYL)PHENYL]-1H-IMIDAZOL-4-YL}PYRIDINE'>R09</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4usd|4usd]], [[4usf|4usf]]</td></tr>
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Description: Human STK10 (LOK) with SB-633825
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4use FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4use OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4use RCSB], [http://www.ebi.ac.uk/pdbsum/4use PDBsum]</span></td></tr>
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[[Category: Elkins, J.M]]
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/STK10_HUMAN STK10_HUMAN]] The disease may be caused by mutations affecting the gene represented in this entry.<ref>PMID:16175573</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/STK10_HUMAN STK10_HUMAN]] Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo.<ref>PMID:11903060</ref> <ref>PMID:12639966</ref> <ref>PMID:19255442</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Bountra, C]]
[[Category: Canning, P]]
[[Category: Canning, P]]
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[[Category: Vondelft, F]]
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[[Category: Edwards, A M]]
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[[Category: Elkins, J M]]
[[Category: Knapp, S]]
[[Category: Knapp, S]]
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[[Category: Bountra, C]]
 
[[Category: Raynor, J]]
[[Category: Raynor, J]]
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[[Category: Szklarz, M]]
 
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[[Category: Edwards, A.M]]
 
[[Category: Salah, E]]
[[Category: Salah, E]]
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[[Category: Szklarz, M]]
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[[Category: VonDelft, F]]
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[[Category: Transferase]]

Revision as of 14:16, 22 July 2015

Human STK10 (LOK) with SB-633825

4use, resolution 2.65Å

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