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Autophagy-related protein
From Proteopedia
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(New page: <StructureSection load='3vh3' size='340' side='right' caption='Yeast Atg7 C terminal complex with Atg8 (PDB code 3vh3)' scene=''> '''Autophagy-related proteins''' (Atg) function in au...) |
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| - | + | <StructureSection load='3vh3' size='340' side='right' caption='Yeast Atg7 C terminal (grey) complex with Atg8 (green) and Zn+2 ion (grey) (PDB code [[3vh3]])' scene=''> | |
| - | <StructureSection load='3vh3' size='340' side='right' caption='Yeast Atg7 C terminal complex with Atg8 (PDB code [[3vh3]])' scene=''> | + | |
'''Autophagy-related proteins''' (Atg) function in autophagosome formation from the pre-autophagosomal structure (PAS). The phagosomes perform protein degradation under starvation. Autophagy is the process of forming a vacuole around proteins or nucleic acids destined to be broken down. This vacuole is a double membrane enclosure called phagophore. Atgs have non-autophagic functions as well as they are involved in cell survival and apoptosis. So far 34 Atgs have been identified in yeast. <br /> | '''Autophagy-related proteins''' (Atg) function in autophagosome formation from the pre-autophagosomal structure (PAS). The phagosomes perform protein degradation under starvation. Autophagy is the process of forming a vacuole around proteins or nucleic acids destined to be broken down. This vacuole is a double membrane enclosure called phagophore. Atgs have non-autophagic functions as well as they are involved in cell survival and apoptosis. So far 34 Atgs have been identified in yeast. <br /> | ||
*'''Atg1, 6, 14''' are involved in the formation of the phagophore. <br /> | *'''Atg1, 6, 14''' are involved in the formation of the phagophore. <br /> | ||
*'''Atg3''' catalyzes the conjugation of Atg8 and phosphatidylethanolamine. This conjugation is essential for autophagosome formation. <br /> | *'''Atg3''' catalyzes the conjugation of Atg8 and phosphatidylethanolamine. This conjugation is essential for autophagosome formation. <br /> | ||
*'''Atg4, 5, 7, 10, 16''' are involved in the maturation of the phagophore.<br /> | *'''Atg4, 5, 7, 10, 16''' are involved in the maturation of the phagophore.<br /> | ||
| - | *'''Atg8''' is structurally similar to ubiquitin. It is a targeting factor in cytoplasm-to-vacuole transport of proteins such as aminopeptidase and a-mannosidase.<br /> | + | *'''Atg8''' is structurally similar to ubiquitin. It is a targeting factor in cytoplasm-to-vacuole transport of proteins such as aminopeptidase and a-mannosidase. [[Microtubule-associated protein light chain 3]] '''LC3''' is a mammalian Atg8.<br /> |
*'''Atg12''' is involved in the elongation of the phagophore.<br /> | *'''Atg12''' is involved in the elongation of the phagophore.<br /> | ||
*'''Atg13, 17''' are PAS scaffold proteins. <br /> | *'''Atg13, 17''' are PAS scaffold proteins. <br /> | ||
*'''Atg101''' is believed to protect Atg13 from proteasomal degradation. | *'''Atg101''' is believed to protect Atg13 from proteasomal degradation. | ||
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== Function == | == Function == | ||
Revision as of 09:24, 27 July 2015
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3D Structures of autophagy-related protein
Updated on 27-July-2015
References
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Jaime Prilusky, Joel L. Sussman
