Hydroxysteroid dehydrogenase
From Proteopedia
(Difference between revisions)
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**[[1afs]] - rHSD + hydroxysteroid + NADP<BR /> | **[[1afs]] - rHSD + hydroxysteroid + NADP<BR /> | ||
| - | **[[4jq1]], [[4jq2]], [[4jq3]], [[4jqa]], [[4jqa]], [[4jtq]], [[4jtr]] - hHSD + NSAID drug + NADP - human<br /> | + | **[[4jq1]], [[4jq2]], [[4jq3]], [[4jq4]], [[4jqa]], [[4jqa]], [[4jtq]], [[4jtr]] - hHSD + NSAID drug + NADP - human<br /> |
*3-α HSD type 3 | *3-α HSD type 3 | ||
Revision as of 10:09, 27 July 2015
Template:STRUCTURE 1lwi
Hydroxysteroid dehydrogenase (HSD) catalyzes the dehydrogenation of hydroxysteroids. HSD is classified according to the number of carbon it is acting on.
- 3-α HSD catalyzes the conversion of androsterone to 5α-androstane-3, 17-dione and 17-α estradiol to estrone. 3-α HSD (also named 17-α HSD) is a bile acid-metabolizing enzyme.
- 7-α HSD is involved in the dehydrogenation of cholanate compounds and is a bile acid-inducible enzyme.
- 20-α HSD is involved in the control of progesterone level in pregnancy of mice.
- 11-β HSD converts 11-keto products like cortisone to cortisol.
- 17-β HSD is involved in the conversion of androstenedione to testosterone.
- 3-β/17-β HSD catalyzes the reversible dehydrogenation of steroid compounds at position 3 and 17.
NAD and NADP are cofactors of HSD.
3D structures of hydroxysteroid dehydrogenase
Updated on 27-July-2015
For 3-α HSD type 2 see Prostaglandin F synthase
For 17-β HSD type 5 see Prostaglandin F synthase
