This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
6tmn
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:6tmn.gif|left|200px]] | + | [[Image:6tmn.gif|left|200px]] |
| - | + | ||
| - | '''STRUCTURES OF TWO THERMOLYSIN-INHIBITOR COMPLEXES THAT DIFFER BY A SINGLE HYDROGEN BOND''' | + | {{Structure |
| + | |PDB= 6tmn |SIZE=350|CAPTION= <scene name='initialview01'>6tmn</scene>, resolution 1.6Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=ZN:ZINC ION'>ZN</scene> | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Thermolysin Thermolysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.27 3.4.24.27] | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''STRUCTURES OF TWO THERMOLYSIN-INHIBITOR COMPLEXES THAT DIFFER BY A SINGLE HYDROGEN BOND''' | ||
| + | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | 6TMN is a [ | + | 6TMN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TMN OCA]. |
==Reference== | ==Reference== | ||
| - | Structures of two thermolysin-inhibitor complexes that differ by a single hydrogen bond., Tronrud DE, Holden HM, Matthews BW, Science. 1987 Jan 30;235(4788):571-4. PMID:[http:// | + | Structures of two thermolysin-inhibitor complexes that differ by a single hydrogen bond., Tronrud DE, Holden HM, Matthews BW, Science. 1987 Jan 30;235(4788):571-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/3810156 3810156] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Thermolysin]] | [[Category: Thermolysin]] | ||
| Line 20: | Line 29: | ||
[[Category: hydrolase (metalloproteinase)]] | [[Category: hydrolase (metalloproteinase)]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 19:14:06 2008'' |
Revision as of 17:14, 20 March 2008
| |||||||
| , resolution 1.6Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | and | ||||||
| Activity: | Thermolysin, with EC number 3.4.24.27 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
STRUCTURES OF TWO THERMOLYSIN-INHIBITOR COMPLEXES THAT DIFFER BY A SINGLE HYDROGEN BOND
Overview
The mode of binding to thermolysin of the ester analog Cbz-GlyP-(O)-Leu-Leu has been determined by x-ray crystallography and shown to be virtually identical (maximum difference 0.2 angstrom) with the corresponding peptide analog Cbz-GlyP-(NH)-Leu-Leu. The two inhibitors provide a matched pair of enzyme-inhibitor complexes that differ by 4.1 kilocalories per mole in intrinsic binding energy but are essentially identical except for the presence or absence of a specific hydrogen bond.
About this Structure
6TMN is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.
Reference
Structures of two thermolysin-inhibitor complexes that differ by a single hydrogen bond., Tronrud DE, Holden HM, Matthews BW, Science. 1987 Jan 30;235(4788):571-4. PMID:3810156
Page seeded by OCA on Thu Mar 20 19:14:06 2008
