3x44
From Proteopedia
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| - | ''' | + | ==Crystal structure of O-ureido-L-serine-bound K43A mutant of O-ureido-L-serine synthase== |
| - | + | <StructureSection load='3x44' size='340' side='right' caption='[[3x44]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3x44]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3X44 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3X44 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PUS:(E)-O-(CARBAMOYLAMINO)-N-({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYLIDENE)-L-SERINE'>PUS</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3x44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3x44 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3x44 RCSB], [http://www.ebi.ac.uk/pdbsum/3x44 PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [[http://www.uniprot.org/uniprot/DCSD_STRLA DCSD_STRLA]] Involved in the biosynthesis of the antibiotic D-cycloserine (DCS), a cyclic structural analog of D-alanine, used as an antitubercular agent. Catalyzes the addition of hydroxyurea on O-acetyl-L-serine (OAS) to yield O-ureido-L-serine. It prefers sulfide as the second substrate, followed by hydroxyurea, L-homocysteine, and thiosulfate.<ref>PMID:20086163</ref> <ref>PMID:23529730</ref> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Matoba, Y]] | [[Category: Matoba, Y]] | ||
| - | [[Category: | + | [[Category: Oda, K]] |
[[Category: Sugiyama, M]] | [[Category: Sugiyama, M]] | ||
| + | [[Category: Uda, N]] | ||
| + | [[Category: D-cycloserine]] | ||
| + | [[Category: Synthase]] | ||
| + | [[Category: Transferase]] | ||
| + | [[Category: Type ii plp enzyme]] | ||
Revision as of 14:45, 29 July 2015
Crystal structure of O-ureido-L-serine-bound K43A mutant of O-ureido-L-serine synthase
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Categories: Matoba, Y | Oda, K | Sugiyama, M | Uda, N | D-cycloserine | Synthase | Transferase | Type ii plp enzyme
