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2cmz
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
| - | 2CMZ is a | + | 2CMZ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Vesicular_stomatitis_indiana_virus Vesicular stomatitis indiana virus] with CA and PE4 as [http://en.wikipedia.org/wiki/ligands ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CMZ OCA]. |
==Reference== | ==Reference== | ||
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[[Category: transmembrane]] | [[Category: transmembrane]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 14:29:44 2007'' |
Revision as of 12:24, 5 November 2007
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CRYSTAL STRUCTURE OF VSV-INDIANA (MUDD-SUMMERS STRAIN) GLYCOPROTEIN UNDER ITS ACIDIC CONFORMATION
Overview
The vesicular stomatitis virus has an atypical membrane fusion, glycoprotein (G) exhibiting a pH-dependent equilibrium between two forms, at the virus surface. Membrane fusion is triggered during the transition, from the high- to low-pH form. The structure of G in its low-pH form shows, the classic hairpin conformation observed in all other fusion proteins in, their postfusion conformation, in spite of a novel fold combining features, of fusion proteins from classes I and II. The structure provides a, framework for understanding the reversibility of the G conformational, change. Unexpectedly, G is homologous to gB of herpesviruses, which raises, important questions on viral evolution.
About this Structure
2CMZ is a Single protein structure of sequence from Vesicular stomatitis indiana virus with CA and PE4 as ligands. Structure known Active Site: AC1. Full crystallographic information is available from OCA.
Reference
Crystal structure of the low-pH form of the vesicular stomatitis virus glycoprotein G., Roche S, Bressanelli S, Rey FA, Gaudin Y, Science. 2006 Jul 14;313(5784):187-91. PMID:16840692
Page seeded by OCA on Mon Nov 5 14:29:44 2007
