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5c6g

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'''Unreleased structure'''
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==Structural Insights into the Scc2-Scc4 Cohesin Loader==
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<StructureSection load='5c6g' size='340' side='right' caption='[[5c6g]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5c6g]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C6G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5C6G FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5c6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c6g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5c6g RCSB], [http://www.ebi.ac.uk/pdbsum/5c6g PDBsum]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/SCC2_ASHGO SCC2_ASHGO]] Plays a structural role in chromatin. Probably involved in sister chromatid cohesion, possibly by interacting with the cohesin complex (By similarity).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The remarkable accuracy of eukaryotic cell division is partly maintained by the cohesin complex acting as a molecular glue to prevent premature sister chromatid separation. The loading of cohesin onto chromosomes is catalyzed by the Scc2-Scc4 loader complex. Here, we report the crystal structure of Scc4 bound to the N terminus of Scc2 and show that Scc4 is a tetratricopeptide repeat (TPR) superhelix. The Scc2 N terminus adopts an extended conformation and is entrapped by the core of the Scc4 superhelix. Electron microscopy (EM) analysis reveals that the Scc2-Scc4 loader complex comprises three domains: a head, body, and hook. Deletion studies unambiguously assign the Scc2N-Scc4 as the globular head domain, whereas in vitro cohesin loading assays show that the central body and the hook domains are sufficient to catalyze cohesin loading onto circular DNA, but not chromatinized DNA in vivo, suggesting a possible role for Scc4 as a chromatin adaptor.
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The entry 5c6g is ON HOLD until Paper Publication
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Structural Studies Reveal the Functional Modularity of the Scc2-Scc4 Cohesin Loader.,Chao WC, Murayama Y, Munoz S, Costa A, Uhlmann F, Singleton MR Cell Rep. 2015 Jul 22. pii: S2211-1247(15)00709-3. doi:, 10.1016/j.celrep.2015.06.071. PMID:26212329<ref>PMID:26212329</ref>
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Authors: Singleton, M.R., Chao, W.C.H.
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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Description:
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Chao, W.C.H]]
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__TOC__
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[[Category: Singleton, M.R]]
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</StructureSection>
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[[Category: Chao, W C.H]]
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[[Category: Singleton, M R]]
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[[Category: Cell cycle]]
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[[Category: Cohesin loader]]
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[[Category: Tpr repeat]]

Revision as of 20:06, 5 August 2015

Structural Insights into the Scc2-Scc4 Cohesin Loader

5c6g, resolution 2.60Å

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