4wn5
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Crystal structure of the C-terminal Per-Arnt-Sim (PASb) of human HIF-3alpha9 bound to 18:1-1-monoacylglycerol== |
| - | + | <StructureSection load='4wn5' size='340' side='right' caption='[[4wn5]], [[Resolution|resolution]] 1.15Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4wn5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WN5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WN5 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MVC:MONOVACCENIN'>MVC</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wn5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wn5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wn5 RCSB], [http://www.ebi.ac.uk/pdbsum/4wn5 PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [[http://www.uniprot.org/uniprot/HIF3A_HUMAN HIF3A_HUMAN]] Acts as a transcriptional regulator in adaptive response to low oxygen tension. Acts as a regulator of hypoxia-inducible gene expression (PubMed:11573933, PubMed:16126907, PubMed:19694616, PubMed:20416395, PubMed:21069422). Functions as an inhibitor of angiogenesis in hypoxic cells of the cornea. Plays a role in the development of the cardiorespiratory system. May also be involved in apoptosis (By similarity).[UniProtKB:Q0VBL6]<ref>PMID:11573933</ref> <ref>PMID:16126907</ref> <ref>PMID:19694616</ref> <ref>PMID:20416395</ref> <ref>PMID:21069422</ref> Isoform 2: Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation. Also inhibits hypoxia-inducible ARNT-mediated gene expression.<ref>PMID:11573933</ref> Isoform 3: Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation.<ref>PMID:19694616</ref> <ref>PMID:20416395</ref> <ref>PMID:21069422</ref> isoform 4: Attenuates the ability of transcription factor HIF1A and EPAS1/HIF2A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation (PubMed:16126907, PubMed:17998805, PubMed:19694616, PubMed:20416395). May act as a tumor suppressor and inhibits malignant cell transformation (PubMed:17998805).<ref>PMID:16126907</ref> <ref>PMID:17998805</ref> <ref>PMID:19694616</ref> <ref>PMID:20416395</ref> Isoform 5: Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation.<ref>PMID:21069422</ref> |
| - | [[Category: Fala, A | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Ambrosio, A L]] | ||
| + | [[Category: Dias, S M]] | ||
| + | [[Category: Fala, A M]] | ||
| + | [[Category: Oliveira, J F]] | ||
| + | [[Category: Fatty acid]] | ||
| + | [[Category: Hif-3alpha]] | ||
| + | [[Category: Lipid]] | ||
| + | [[Category: Monoacylglycerol]] | ||
| + | [[Category: Pas domain]] | ||
| + | [[Category: Transcription]] | ||
Revision as of 20:11, 5 August 2015
Crystal structure of the C-terminal Per-Arnt-Sim (PASb) of human HIF-3alpha9 bound to 18:1-1-monoacylglycerol
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