5bon
From Proteopedia
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| - | ''' | + | ==Crystal structure of human Nudt15 (MTH2)== |
| - | + | <StructureSection load='5bon' size='340' side='right' caption='[[5bon]], [[Resolution|resolution]] 1.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5bon]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BON OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BON FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/8-oxo-dGTP_diphosphatase 8-oxo-dGTP diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.55 3.6.1.55] </span></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bon FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bon OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5bon RCSB], [http://www.ebi.ac.uk/pdbsum/5bon PDBsum]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NUD15_HUMAN NUD15_HUMAN]] Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro, suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions. Its substrate specificity in vivo however remains unclear (By similarity). May have a role in DNA synthesis and cell cycle progression through the interaction with PCNA.<ref>PMID:19419956</ref> <ref>PMID:22556419</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: 8-oxo-dGTP diphosphatase]] | ||
| + | [[Category: Carter, M]] | ||
[[Category: Helleday, T]] | [[Category: Helleday, T]] | ||
| - | [[Category: Jemth, A | + | [[Category: Jemth, A S]] |
[[Category: Stenmark, P]] | [[Category: Stenmark, P]] | ||
| - | [[Category: | + | [[Category: Dimer]] |
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Magnesium]] | ||
| + | [[Category: Mth2]] | ||
| + | [[Category: Nucleotide]] | ||
| + | [[Category: Nudix]] | ||
| + | [[Category: Nudt15]] | ||
Revision as of 20:19, 5 August 2015
Crystal structure of human Nudt15 (MTH2)
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Categories: 8-oxo-dGTP diphosphatase | Carter, M | Helleday, T | Jemth, A S | Stenmark, P | Dimer | Hydrolase | Magnesium | Mth2 | Nucleotide | Nudix | Nudt15
