4qe8
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==FXR with DM175 and NCoA-2 peptide== |
| - | + | <StructureSection load='4qe8' size='340' side='right' caption='[[4qe8]], [[Resolution|resolution]] 2.62Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4qe8]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QE8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QE8 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=31D:4-({2-[(4-TERT-BUTYLBENZOYL)AMINO]BENZOYL}AMINO)BENZOIC+ACID'>31D</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4qe6|4qe6]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qe8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qe8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qe8 RCSB], [http://www.ebi.ac.uk/pdbsum/4qe8 PDBsum]</span></td></tr> | |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Disease == |
| + | [[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN]] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref> [[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.<ref>PMID:9430642</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bamberg, K]] | ||
| + | [[Category: Dekker, N]] | ||
[[Category: Kudlinzki, D]] | [[Category: Kudlinzki, D]] | ||
| + | [[Category: Linhard, V L]] | ||
| + | [[Category: Merk, D]] | ||
| + | [[Category: Nilsson, E]] | ||
[[Category: Saxena, K]] | [[Category: Saxena, K]] | ||
[[Category: Schubert-Zsilavecz, M]] | [[Category: Schubert-Zsilavecz, M]] | ||
| - | [[Category: Merk, D]] | ||
[[Category: Schwalbe, H]] | [[Category: Schwalbe, H]] | ||
[[Category: Sreeramulu, S]] | [[Category: Sreeramulu, S]] | ||
| + | [[Category: Wissler, L]] | ||
| + | [[Category: Bile acid receptor dna]] | ||
| + | [[Category: Receptor]] | ||
| + | [[Category: Transcription]] | ||
Revision as of 14:44, 12 August 2015
FXR with DM175 and NCoA-2 peptide
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