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4uqm
From Proteopedia
(Difference between revisions)
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| - | + | ==Crystal structure determination of uracil-DNA N-glycosylase (UNG) from Deinococcus radiodurans in complex with DNA - new insights into the role of the Leucine-loop for damage recognition and repair== | |
| - | + | <StructureSection load='4uqm' size='340' side='right' caption='[[4uqm]], [[Resolution|resolution]] 1.35Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4uqm]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UQM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UQM FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |
| - | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=AAB:2-DEOXY-RIBOFURANOSE-5-MONOPHOSPHATE'>AAB</scene></td></tr> | |
| - | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Uracil-DNA_glycosylase Uracil-DNA glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.27 3.2.2.27] </span></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uqm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uqm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uqm RCSB], [http://www.ebi.ac.uk/pdbsum/4uqm PDBsum]</span></td></tr> |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/UNG_DEIRA UNG_DEIRA]] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Uracil-DNA glycosylase]] | ||
| + | [[Category: Johnson, K A]] | ||
[[Category: Leiros, I]] | [[Category: Leiros, I]] | ||
| - | [[Category: | + | [[Category: McVey, C E]] |
[[Category: Moe, E]] | [[Category: Moe, E]] | ||
| + | [[Category: Pedersen, H L]] | ||
| + | [[Category: Base excision repair]] | ||
| + | [[Category: Dna damage]] | ||
| + | [[Category: Dna repair]] | ||
| + | [[Category: Hydrolase-dna complex]] | ||
| + | [[Category: Protein-dna complex]] | ||
| + | [[Category: Radiation resistance]] | ||
Revision as of 14:47, 12 August 2015
Crystal structure determination of uracil-DNA N-glycosylase (UNG) from Deinococcus radiodurans in complex with DNA - new insights into the role of the Leucine-loop for damage recognition and repair
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