4ytx

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'''Unreleased structure'''
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==Crystal structure of Ups1-Mdm35 complex with PA==
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<StructureSection load='4ytx' size='340' side='right' caption='[[4ytx]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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The entry 4ytx is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ytx]] is a 16 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YTX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YTX FirstGlance]. <br>
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Authors: Watanabe, Y., Tamura, Y., Kawano, S., Endo, T.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PX2:1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE'>PX2</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ytv|4ytv]], [[4ytw|4ytw]]</td></tr>
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Description:
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ytx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ytx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ytx RCSB], [http://www.ebi.ac.uk/pdbsum/4ytx PDBsum]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Tamura, Y]]
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== Function ==
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[[Category: Watanabe, Y]]
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[[http://www.uniprot.org/uniprot/MDM35_YEAST MDM35_YEAST]] Involved in mitochondrial distribution and morphology. Mediates the import of UPS1, UPS2 and UPS3, 3 atypical mitochondrial intermembrane space (IMS) proteins lacking the two major IMS-targeting signals, into the intermembrane space.<ref>PMID:11907266</ref> <ref>PMID:20622808</ref> <ref>PMID:20657548</ref> [[http://www.uniprot.org/uniprot/UPS1_YEAST UPS1_YEAST]] Required for maintenance of normal mitochondrial morphology as well as PCP1-dependent processing of MGM1. With UPS2, controls the level of cardiolipin in mitochondria. Cardiolipin is a unique phospholipid with four fatty acid chains and is present mainly in the mitochondrial inner membrane where it stabilizes the electron transport chain supercomplex between complexes III and IV through direct interaction of their subunits.<ref>PMID:16754953</ref> <ref>PMID:19221197</ref> <ref>PMID:19506038</ref> <ref>PMID:20622808</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Endo, T]]
[[Category: Endo, T]]
[[Category: Kawano, S]]
[[Category: Kawano, S]]
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[[Category: Tamura, Y]]
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[[Category: Watanabe, Y]]
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[[Category: Lipid transport]]
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[[Category: Mitochondria]]
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[[Category: Phosphatidic acid]]
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[[Category: Phospholipid transfer]]

Revision as of 14:51, 12 August 2015

Crystal structure of Ups1-Mdm35 complex with PA

4ytx, resolution 3.20Å

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