3jah
From Proteopedia
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| - | ''' | + | ==Structure of a mammalian ribosomal termination complex with ABCE1, eRF1(AAQ), and the UAG stop codon== |
| - | + | <StructureSection load='3jah' size='340' side='right' caption='[[3jah]], [[Resolution|resolution]] 3.45Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3jah]] is a 87 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JAH FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3jag|3jag]], [[3jai|3jai]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jah OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jah RCSB], [http://www.ebi.ac.uk/pdbsum/3jah PDBsum]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/U3KPD5_RABIT U3KPD5_RABIT]] Binds to the 23S rRNA.[RuleBase:RU000576] [[http://www.uniprot.org/uniprot/ERF1_HUMAN ERF1_HUMAN]] Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.<ref>PMID:7990965</ref> [[http://www.uniprot.org/uniprot/G1SS70_RABIT G1SS70_RABIT]] May play a role during erythropoiesis through regulation of transcription factor DDIT3.[HAMAP-Rule:MF_03122] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Oryctolagus cuniculus]] | ||
[[Category: Brown, A]] | [[Category: Brown, A]] | ||
| - | [[Category: | + | [[Category: Hegde, R S]] |
[[Category: Murray, J]] | [[Category: Murray, J]] | ||
| - | [[Category: Hegde, R.S]] | ||
[[Category: Ramakrishnan, V]] | [[Category: Ramakrishnan, V]] | ||
| + | [[Category: Shao, S]] | ||
| + | [[Category: Abce1]] | ||
| + | [[Category: Erf1]] | ||
| + | [[Category: Ribosome]] | ||
| + | [[Category: Termination]] | ||
Revision as of 14:57, 12 August 2015
Structure of a mammalian ribosomal termination complex with ABCE1, eRF1(AAQ), and the UAG stop codon
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Categories: Oryctolagus cuniculus | Brown, A | Hegde, R S | Murray, J | Ramakrishnan, V | Shao, S | Abce1 | Erf1 | Ribosome | Termination
