1cgp

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|PDB= 1cgp |SIZE=350|CAPTION= <scene name='initialview01'>1cgp</scene>, resolution 3.000&Aring;
|PDB= 1cgp |SIZE=350|CAPTION= <scene name='initialview01'>1cgp</scene>, resolution 3.000&Aring;
|SITE=
|SITE=
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|LIGAND= <scene name='pdbligand=CMP:ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE'>CMP</scene>
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|LIGAND= <scene name='pdbligand=CMP:ADENOSINE-3&#39;,5&#39;-CYCLIC-MONOPHOSPHATE'>CMP</scene>
|ACTIVITY=
|ACTIVITY=
|GENE=
|GENE=
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[[Category: protein-dna complex]]
[[Category: protein-dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:24:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 11:22:40 2008''

Revision as of 09:22, 23 March 2008

Image:1cgp.gif


PDB ID 1cgp

Drag the structure with the mouse to rotate
, resolution 3.000Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



CATABOLITE GENE ACTIVATOR PROTEIN (CAP)/DNA COMPLEX + ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE


Overview

The 3 angstrom resolution crystal structure of the Escherichia coli catabolite gene activator protein (CAP) complexed with a 30-base pair DNA sequence shows that the DNA is bent by 90 degrees. This bend results almost entirely from two 40 degrees kinks that occur between TG/CA base pairs at positions 5 and 6 on each side of the dyad axis of the complex. DNA sequence discrimination by CAP derives both from sequence-dependent distortion of the DNA helix and from direct hydrogen-bonding interactions between three protein side chains and the exposed edges of three base pairs in the major groove of the DNA. The structure of this transcription factor--DNA complex provides insights into possible mechanisms of transcription activation.

About this Structure

1CGP is a Single protein structure of sequence from Escherichia coli. The following page contains interesting information on the relation of 1CGP with [Catabolite Activator Protein]. Full crystallographic information is available from OCA.

Reference

Crystal structure of a CAP-DNA complex: the DNA is bent by 90 degrees., Schultz SC, Shields GC, Steitz TA, Science. 1991 Aug 30;253(5023):1001-7. PMID:1653449

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