5bqn
From Proteopedia
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| - | ''' | + | ==Crystal structure of the LHn fragment of botulinum neurotoxin type D, mutant H233Y E230Q== |
| - | + | <StructureSection load='5bqn' size='340' side='right' caption='[[5bqn]], [[Resolution|resolution]] 2.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5bqn]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BQN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BQN FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bqn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5bqn RCSB], [http://www.ebi.ac.uk/pdbsum/5bqn PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | [[ | + | == Function == |
| - | [[Category: Acharya, K | + | [[http://www.uniprot.org/uniprot/BXD_CLOBO BXD_CLOBO]] Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '60-Lys-|-Leu-61' bond of synaptobrevins-1 and -2. |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| + | [[Category: Acharya, K R]] | ||
| + | [[Category: Chaddock, J A]] | ||
| + | [[Category: Davies, J R]] | ||
[[Category: Masuyer, G]] | [[Category: Masuyer, G]] | ||
| - | [[Category: | + | [[Category: Moore, K]] |
| + | [[Category: Botulinum neurotoxin]] | ||
| + | [[Category: Endopeptidase]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Protein engineering]] | ||
| + | [[Category: Targeted secretion inhibitor]] | ||
| + | [[Category: Type d]] | ||
Revision as of 12:28, 20 August 2015
Crystal structure of the LHn fragment of botulinum neurotoxin type D, mutant H233Y E230Q
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