5cqs

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'''Unreleased structure'''
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==Dimerization of Elp1 is essential for Elongator complex assembly==
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<StructureSection load='5cqs' size='340' side='right' caption='[[5cqs]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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The entry 5cqs is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5cqs]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CQS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CQS FirstGlance]. <br>
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Authors: Lin, Z., Xu, H., Li, F., Diao, W., Long, J., Shen, Y.
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5cqr|5cqr]]</td></tr>
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Description: Dimerization of Elp1 is essential for Elongator complex assembly
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cqs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5cqs RCSB], [http://www.ebi.ac.uk/pdbsum/5cqs PDBsum]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Shen, Y]]
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== Function ==
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[[http://www.uniprot.org/uniprot/ELP1_YEAST ELP1_YEAST]] Acts as component of the RNA polymerase II elongator complex, which is a major histone acetyltransferase component of the RNA polymerase II (RNAPII) holoenzyme and is involved in transcriptional elongation. Association with elongating RNAPII requires a hyperphosphorylated state of the RNAPII C-terminal domain (CTD). Elongator binds to both naked and nucleosomal DNA, can acetylate both core and nucleosomal histones, and is involved in chromatin remodeling. It acetylates histones H3, preferentially at 'Lys-14', and H4, preferentially at 'Lys-8'. It functions as a gamma-toxin target (TOT); disruption of the complex confers resistance to Kluyveromyces lactis toxin zymocin (pGKL1 killer toxin). May also be involved in sensitiviy to Pichia inositovora toxin. May be involved in tRNA modification. Independently, ELP3 may be involved in polarized exocytosis. It is required for the polarized localization of GTPase-activating protein SEC2. Is required for an early step in synthesis of 5-methoxycarbonylmethyl (mcm5) and 5-carbamoylmethyl (ncm5) groups present on uridines at the wobble position in tRNA.<ref>PMID:10024884</ref> <ref>PMID:11296232</ref> <ref>PMID:11689709</ref> <ref>PMID:11904415</ref> <ref>PMID:12424236</ref> <ref>PMID:13680368</ref> <ref>PMID:15769872</ref> <ref>PMID:15780940</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Diao, W]]
[[Category: Li, F]]
[[Category: Li, F]]
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[[Category: Xu, H]]
 
[[Category: Lin, Z]]
[[Category: Lin, Z]]
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[[Category: Diao, W]]
 
[[Category: Long, J]]
[[Category: Long, J]]
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[[Category: Shen, Y]]
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[[Category: Xu, H]]
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[[Category: Dimerization]]
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[[Category: Elongator complex]]
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[[Category: Elp1 subunit]]
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[[Category: Familial dysautonomia]]
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[[Category: Protein binding]]

Revision as of 12:28, 20 August 2015

Dimerization of Elp1 is essential for Elongator complex assembly

5cqs, resolution 2.70Å

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