5d3i

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m (Protected "5d3i" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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==Crystal structure of the SSL3-TLR2 complex==
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<StructureSection load='5d3i' size='340' side='right' caption='[[5d3i]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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The entry 5d3i is ON HOLD
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5d3i]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D3I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D3I FirstGlance]. <br>
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Authors: Feitsma, Louris J., Koymans, Kirsten J., Brondijk, T.Harma C., Aerts, Piet C., Lukkien, Eddie, Kessel, Kok P.M.van, Strijp, Jos A.G.van, Huizinga, Eric G.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PCW:1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PCW</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5d3d|5d3d]]</td></tr>
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Description: Crystal structure of the SSL3-TLR2 complex
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d3i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5d3i RCSB], [http://www.ebi.ac.uk/pdbsum/5d3i PDBsum]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Koymans, Kirsten J]]
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== Function ==
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[[Category: Lukkien, Eddie, Kessel, Kok P.M.Van, Strijp, Jos A.G.Van, Huizinga, Eric G]]
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[[http://www.uniprot.org/uniprot/TLR2_MOUSE TLR2_MOUSE]] Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins (By similarity).<ref>PMID:19931471</ref>
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[[Category: Brondijk, T.Harma C]]
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== References ==
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[[Category: Feitsma, Louris J]]
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<references/>
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[[Category: Aerts, Piet C]]
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__TOC__
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</StructureSection>
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[[Category: Feitsma, L J]]
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[[Category: Huizinga, E G]]
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[[Category: Immune evasion]]
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[[Category: Immune system]]
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[[Category: Immunology]]
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[[Category: Inflammation]]
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[[Category: Inhibition]]
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[[Category: Innate immunity]]
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[[Category: Lipopeptide]]
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[[Category: Pc]]
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[[Category: Phosphatidylcholine]]
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[[Category: Ssl]]
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[[Category: Ssl3]]
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[[Category: Superantigen-like protein]]
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[[Category: Superantigen]]
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[[Category: Tlr2]]
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[[Category: Tlr6]]
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[[Category: Toll-like receptor 2]]

Revision as of 12:29, 20 August 2015

Crystal structure of the SSL3-TLR2 complex

5d3i, resolution 3.20Å

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