1ej1

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|PDB= 1ej1 |SIZE=350|CAPTION= <scene name='initialview01'>1ej1</scene>, resolution 2.2&Aring;
|PDB= 1ej1 |SIZE=350|CAPTION= <scene name='initialview01'>1ej1</scene>, resolution 2.2&Aring;
|SITE=
|SITE=
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|LIGAND= <scene name='pdbligand=M7G:7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE'>M7G</scene>
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|LIGAND= <scene name='pdbligand=M7G:7N-METHYL-8-HYDROGUANOSINE-5&#39;-DIPHOSPHATE'>M7G</scene>
|ACTIVITY=
|ACTIVITY=
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[[Category: protein 5' mrna cap complex]]
[[Category: protein 5' mrna cap complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:56:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 11:39:47 2008''

Revision as of 09:39, 23 March 2008

Image:1ej1.jpg


PDB ID 1ej1

Drag the structure with the mouse to rotate
, resolution 2.2Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



COCRYSTAL STRUCTURE OF THE MESSENGER RNA 5' CAP-BINDING PROTEIN (EIF4E) BOUND TO 7-METHYL-GDP


Overview

The X-ray structure of the eukaryotic translation initiation factor 4E (eIF4E), bound to 7-methyl-GDP, has been determined at 2.2 A resolution. eIF4E recognizes 5' 7-methyl-G(5')ppp(5')N mRNA caps during the rate-limiting initiation step of translation. The protein resembles a cupped hand and consists of a curved, 8-stranded antiparallel beta sheet, backed by three long alpha helices. 7-methyl-GDP binds in a narrow cap-binding slot on the molecule's concave surface, where 7-methyl-guanine recognition is mediated by base sandwiching between two conserved tryptophans, plus formation of three hydrogen bonds and a van der Waals contact between its N7-methyl group and a third conserved tryptophan. The convex dorsal surface of the molecule displays a phylogenetically conserved hydrophobic/acidic portion, which may interact with other translation initiation factors and regulatory proteins.

About this Structure

1EJ1 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Cocrystal structure of the messenger RNA 5' cap-binding protein (eIF4E) bound to 7-methyl-GDP., Marcotrigiano J, Gingras AC, Sonenberg N, Burley SK, Cell. 1997 Jun 13;89(6):951-61. PMID:9200613

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