1gd9

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|PDB= 1gd9 |SIZE=350|CAPTION= <scene name='initialview01'>1gd9</scene>, resolution 1.8&Aring;
|PDB= 1gd9 |SIZE=350|CAPTION= <scene name='initialview01'>1gd9</scene>, resolution 1.8&Aring;
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|LIGAND= <scene name='pdbligand=PLP:PYRIDOXAL-5'-PHOSPHATE'>PLP</scene>
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|LIGAND= <scene name='pdbligand=PLP:PYRIDOXAL-5&#39;-PHOSPHATE'>PLP</scene>
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[[Category: temperature dependence of substrate recognition]]
[[Category: temperature dependence of substrate recognition]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:21:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 11:55:11 2008''

Revision as of 09:55, 23 March 2008

Image:1gd9.jpg


PDB ID 1gd9

Drag the structure with the mouse to rotate
, resolution 1.8Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



CRYSTALL STRUCTURE OF PYROCOCCUS PROTEIN-A1


Overview

We determined the crystal structure of the liganded form of alpha-aminotransferase from a hyperthermophile, Pyrococcus horikoshii. This hyperthermophilic enzyme did not show domain movement upon binding of an acidic substrate, glutamate, except for a small movement of the alpha-helix from Glu16 to Ala25. The omega-carboxyl group of the acidic substrate was recognized by Tyr70* without its side-chain movement, but not by positively charged Arg or Lys. Compared with the homologous enzymes from Thermus thermophilus HB8 and Escherichia coli, it was suggested that the more thermophilic the enzyme is, the smaller the domain movement is. This rule seems to be applicable to many other enzymes already reported.

About this Structure

1GD9 is a Single protein structure of sequence from Pyrococcus horikoshii. Full crystallographic information is available from OCA.

Reference

Temperature dependence of the enzyme-substrate recognition mechanism., Ura H, Harata K, Matsui I, Kuramitsu S, J Biochem. 2001 Jan;129(1):173-8. PMID:11134972

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