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4v5o

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Revision as of 16:18, 1 September 2015

CRYSTAL STRUCTURE OF THE EUKARYOTIC 40S RIBOSOMAL SUBUNIT IN COMPLEX WITH INITIATION FACTOR 1.

Structural highlights

4v5o is a 70 chain structure with sequence from [1] and Tetrahymena thermophila. This structure supersedes and combines the now removed PDB entries 2xzm and 2xzn. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
NonStd Res:
Resources:	FirstGlance, OCA, RCSB, PDBsum

Warning: this is a large structure, and loading might take a long time or not happen at all.

Publication Abstract from PubMed

Eukaryotic ribosomes are substantially larger and more complex than their bacterial counterparts. Although their core function is conserved, bacterial and eukaryotic protein synthesis differ considerably at the level of initiation. The eukaryotic small ribosomal subunit (40S) plays a central role in this process; it binds initiation factors that facilitate scanning of messenger RNAs and initiation of protein synthesis. We have determined the crystal structure of the Tetrahymena thermophila 40S ribosomal subunit in complex with eukaryotic initiation factor 1 (eIF1) at 3.9 A resolution. The structure reveals the fold of the entire 18S rRNA and of all ribosomal proteins of the 40S subunit and defines the interactions with the eIF1. It provides insights into the eukaryotic-specific aspects of protein synthesis including the function of eIF1, and signaling and regulation mediated by ribosomal proteins RACK1 and rpS6e.

Crystal Structure of the Eukaryotic 40S Ribosomal Subunit in Complex with Initiation Factor 1.,Rabl J, Leibundgut M, Ataide SF, Haag A, Ban N Science. 2010 Dec 23. PMID:21205638^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Rabl J, Leibundgut M, Ataide SF, Haag A, Ban N. Crystal Structure of the Eukaryotic 40S Ribosomal Subunit in Complex with Initiation Factor 1. Science. 2010 Dec 23. PMID:21205638 doi:10.1126/science.1198308

1 Structural highlights
2 Publication Abstract from PubMed
3 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4v5o"

@@ Line 5: / Line 5: @@
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
 <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2xzm|2xzm]], [[2xzn|2xzn]]</td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4v5o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v5o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4v5o RCSB], [http://www.ebi.ac.uk/pdbsum/4v5o PDBsum]</span></td></tr>
 </table>

4v5o

From Proteopedia

Revision as of 16:18, 1 September 2015

CRYSTAL STRUCTURE OF THE EUKARYOTIC 40S RIBOSOMAL SUBUNIT IN COMPLEX WITH INITIATION FACTOR 1.

Structural highlights

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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