5a9v
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Structure of apo BipA== |
| + | <StructureSection load='5a9v' size='340' side='right' caption='[[5a9v]], [[Resolution|resolution]] 3.31Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5a9v]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A9V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A9V FirstGlance]. <br> | ||
| + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5a9w|5a9w]], [[5a9x|5a9x]], [[5a9y|5a9y]], [[5a9z|5a9z]], [[5aa0|5aa0]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a9v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5a9v RCSB], [http://www.ebi.ac.uk/pdbsum/5a9v PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | BPI-inducible protein A (BipA) is a member of the family of ribosome-dependent translational GTPase (trGTPase) factors along with elongation factors G and 4 (EF-G and EF4). Despite being highly conserved in bacteria and playing a critical role in coordinating cellular responses to environmental changes, its structures (isolated and ribosome bound) remain elusive. Here, we present the crystal structures of apo form and GTP analog, GDP, and guanosine-3',5'-bisdiphosphate (ppGpp)-bound BipA. In addition to having a distinctive domain arrangement, the C-terminal domain of BipA has a unique fold. Furthermore, we report the cryo-electron microscopy structure of BipA bound to the ribosome in its active GTP form and elucidate the unique structural attributes of BipA interactions with the ribosome and A-site tRNA in the light of its possible function in regulating translation. | ||
| - | + | Structure of BipA in GTP form bound to the ratcheted ribosome.,Kumar V, Chen Y, Ero R, Ahmed T, Tan J, Li Z, Wong AS, Bhushan S, Gao YG Proc Natl Acad Sci U S A. 2015 Aug 17. pii: 201513216. PMID:26283392<ref>PMID:26283392</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
[[Category: Chen, Y]] | [[Category: Chen, Y]] | ||
| + | [[Category: Ero, R]] | ||
[[Category: Gao, Y]] | [[Category: Gao, Y]] | ||
| - | [[Category: | + | [[Category: Kumar, V]] |
[[Category: Li, Z]] | [[Category: Li, Z]] | ||
| + | [[Category: Ribosomal protein]] | ||
| + | [[Category: Ribosome]] | ||
| + | [[Category: Translational gtpase factor]] | ||
Revision as of 12:25, 2 September 2015
Structure of apo BipA
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