4yp2
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yp2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yp2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4yp2 RCSB], [http://www.ebi.ac.uk/pdbsum/4yp2 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yp2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yp2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4yp2 RCSB], [http://www.ebi.ac.uk/pdbsum/4yp2 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The interaction of momordin, a type 1 ribosome-inactivating protein from Momordica charantia, with NADP(+) and NADPH has been investigated by X-ray diffraction analysis of complexes generated by co-crystallization and crystal soaking. It is known that the proteins of this family readily cleave the adenine-ribose bond of adenosine and related nucleotides in the crystal, leaving the product, adenine, bound to the enzyme active site. Surprisingly, the nicotinamide-ribose bond of oxidized NADP(+) is cleaved, leaving nicotinamide bound in the active site in the same position but in a slightly different orientation to that of the five-membered ring of adenine. No binding or cleavage of NADPH was observed at pH 7.4 in these experiments. These observations are in accord with current views of the enzyme mechanism and may contribute to ongoing searches for effective inhibitors. | ||
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| + | Cleavage of nicotinamide adenine dinucleotide by the ribosome-inactivating protein from Momordica charantia.,Vinkovic M, Dunn G, Wood GE, Husain J, Wood SP, Gill R Acta Crystallogr F Struct Biol Commun. 2015 Sep 1;71(Pt 9):1152-5. doi:, 10.1107/S2053230X15013540. Epub 2015 Aug 25. PMID:26323301<ref>PMID:26323301</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
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| + | ==See Also== | ||
| + | *[[Ribosome inactivating protein|Ribosome inactivating protein]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 05:04, 9 September 2015
Cleavage of nicotinamide adenine dinucleotides by the ribosome inactivating protein from Momordica charantia
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