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2n2f

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'''Unreleased structure'''
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==Solution NMR structure of Dynorphin 1-13 bound to Kappa Opioid Receptor==
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<StructureSection load='2n2f' size='340' side='right' caption='[[2n2f]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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The entry 2n2f is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2n2f]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N2F FirstGlance]. <br>
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Authors: O'Connor, C., White, K., Doncescu, N., Didenko, T., Roth, B.L., Czaplicki, G., Stevens, R.C., Wuthrich, K., Milon, A.
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n2f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2n2f RCSB], [http://www.ebi.ac.uk/pdbsum/2n2f PDBsum]</span></td></tr>
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</table>
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Description: Solution NMR structure of Dynorphin 1-13 bound to Kappa Opioid Receptor
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== Disease ==
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[[Category: Unreleased Structures]]
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[[http://www.uniprot.org/uniprot/PDYN_HUMAN PDYN_HUMAN]] Spinocerebellar ataxia type 23. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[[http://www.uniprot.org/uniprot/PDYN_HUMAN PDYN_HUMAN]] Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity). Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin (By similarity). Leumorphin has a typical opiod activity and may have anti-apoptotic effect.
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__TOC__
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</StructureSection>
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[[Category: Connor, C O]]
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[[Category: Czaplicki, G]]
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[[Category: Didenko, T]]
[[Category: Doncescu, N]]
[[Category: Doncescu, N]]
[[Category: Milon, A]]
[[Category: Milon, A]]
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[[Category: Czaplicki, G]]
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[[Category: Roth, B L]]
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[[Category: Wuthrich, K]]
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[[Category: Stevens, R C]]
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[[Category: Roth, B.L]]
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[[Category: Stevens, R.C]]
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[[Category: White, K]]
[[Category: White, K]]
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[[Category: Didenko, T]]
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[[Category: Wuthrich, K]]
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[[Category: O'Connor, C]]
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[[Category: Gpcr]]
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[[Category: Hormone receptor]]

Revision as of 11:16, 9 September 2015

Solution NMR structure of Dynorphin 1-13 bound to Kappa Opioid Receptor

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