1jvu

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 4: Line 4:
|PDB= 1jvu |SIZE=350|CAPTION= <scene name='initialview01'>1jvu</scene>, resolution 1.78&Aring;
|PDB= 1jvu |SIZE=350|CAPTION= <scene name='initialview01'>1jvu</scene>, resolution 1.78&Aring;
|SITE=
|SITE=
-
|LIGAND= <scene name='pdbligand=C2P:CYTIDINE-2'-MONOPHOSPHATE'>C2P</scene>
+
|LIGAND= <scene name='pdbligand=C2P:CYTIDINE-2&#39;-MONOPHOSPHATE'>C2P</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5]
|ACTIVITY= [http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5]
|GENE=
|GENE=
Line 31: Line 31:
[[Category: protein structure-function]]
[[Category: protein structure-function]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:09:13 2008''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 12:24:18 2008''

Revision as of 10:24, 23 March 2008

Image:1jvu.gif


PDB ID 1jvu

Drag the structure with the mouse to rotate
, resolution 1.78Å
Ligands:
Activity: Pancreatic ribonuclease, with EC number 3.1.27.5
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF RIBONUCLEASE A (COMPLEXED FORM)


Overview

Despite the increasing number of successful determinations of complex protein structures the understanding of their dynamics properties is still rather limited. Using X-ray crystallography, we demonstrate that ribonuclease A (RNase A) undergoes significant domain motions upon ligand binding. In particular, when cytidine 2'-monophosphate binds to RNase A, the structure of the enzyme becomes more compact. Interestingly, our data also show that these structural alterations are fully reversible in the crystal state. These findings provide structural bases for the dynamic behavior of RNase A in the binding of the substrate shown by Petsko and coworkers (Rasmussen et al. Nature 1992;357:423-424). These subtle domain motions may assume functional relevance for more complex system and may play a significant role in the cooperativity of oligomeric enzymes.

About this Structure

1JVU is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Reversible substrate-induced domain motions in ribonuclease A., Vitagliano L, Merlino A, Zagari A, Mazzarella L, Proteins. 2002 Jan 1;46(1):97-104. PMID:11746706

Page seeded by OCA on Sun Mar 23 12:24:18 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1jvu"
Personal tools