4r9h

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'''Unreleased structure'''
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==Crystal structure of dimeric S33C beta-2 microglobulin mutant at 1.9 Angstrom resolution==
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<StructureSection load='4r9h' size='340' side='right' caption='[[4r9h]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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The entry 4r9h is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4r9h]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R9H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R9H FirstGlance]. <br>
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Authors: Halabelian, L., Bolognesi, M., Ricagno, S.
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ra3|4ra3]], [[4rah|4rah]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r9h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4r9h RCSB], [http://www.ebi.ac.uk/pdbsum/4r9h PDBsum]</span></td></tr>
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Description: Crystal structure of dimeric S33C beta-2 microglobulin mutant at 1.9 Angstrom resolution
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</table>
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[[Category: Unreleased Structures]]
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== Disease ==
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[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Bolognesi, M]]
[[Category: Halabelian, L]]
[[Category: Halabelian, L]]
[[Category: Ricagno, S]]
[[Category: Ricagno, S]]
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[[Category: Bolognesi, M]]
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[[Category: Amyloidosis]]
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[[Category: Beta sandwich]]
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[[Category: Covalent dimer]]
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[[Category: Immune system]]
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[[Category: Inclusion body]]
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[[Category: Oligomerization]]
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[[Category: Protein aggregation]]

Revision as of 11:17, 9 September 2015

Crystal structure of dimeric S33C beta-2 microglobulin mutant at 1.9 Angstrom resolution

4r9h, resolution 1.90Å

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